eprintid: 23326
rev_number: 13
eprint_status: archive
userid: 1589
dir: disk0/00/02/33/26
datestamp: 2017-08-09 13:36:41
lastmod: 2024-03-27 13:23:23
status_changed: 2017-08-09 13:36:41
type: article
metadata_visibility: show
creators_name: Baur, Johannes
creators_name: Büntemeyer, Tjark-Ole
creators_name: Megerle, Felix
creators_name: Deutschbein, Timo
creators_name: Spitzweg, Christine
creators_name: Quinkler, Marcus
creators_name: Nawroth, Peter
creators_name: Kroiss, Matthias
creators_name: Germer, Christoph-Thomas
creators_name: Fassnacht, Martin
creators_name: Steger, Ulrich
title: Outcome after resection of Adrenocortical Carcinoma liver metastases: a retrospective study
subjects: ddc-610
divisions: i-910100
abstract: Background: Metastatic Adrenocortical Carcinoma (ACC) is a rare malignancy with a poor 5-year-survival rate (<15%). A surgical approach is recommended in selected patients if complete resection of distant metastasis can be achieved. To date there are only limited data on the outcome after surgical resection of hepatic metastases of ACC.   Methods: A retrospective analysis of the German Adrenocortical Carcinoma Registry was conducted. Patients with liver metastases of ACC but without extrahepatic metastases or incomplete tumour resection were included.   Results: Seventy-seven patients fulfilled these criteria. Forty-three patients underwent resection of liver metastases of ACC. Complete tumour resection (R0) could be achieved in 30 (69.8%). Median overall survival after liver resection was 76.1 months in comparison to 10.1 months in the 34 remaining patients with unresected liver metastases (p < 0.001). However, disease free survival after liver resection was only 9.1 months. Neither resection status (R0/R1) nor extent of liver resection were significant predictive factors for overall survival. Patients with a time interval to the first metastasis/recurrence (TTFR) of greater than 12 months or solitary liver metastases showed significantly prolonged survival.   Conclusions: Liver resection in the case of ACC liver metastases can achieve long term survival with a median overall survival of more than 5 years, but disease free survival is short despite metastasectomy. Time to recurrence and single versus multiple metastases are predictive factors for the outcome.
date: 2017
publisher: BioMed Central
id_scheme: DOI
ppn_swb: 1654709093
own_urn: urn:nbn:de:bsz:16-heidok-233266
language: eng
bibsort: BAURJOHANNOUTCOMEAFT2017
full_text_status: public
publication: BMC Cancer
volume: 17
number: 522
place_of_pub: London; Berlin; Heidelberg
pagerange: 1-10
issn: 1471-2407
citation:   Baur, Johannes ; Büntemeyer, Tjark-Ole ; Megerle, Felix ; Deutschbein, Timo ; Spitzweg, Christine ; Quinkler, Marcus ; Nawroth, Peter ; Kroiss, Matthias ; Germer, Christoph-Thomas ; Fassnacht, Martin ; Steger, Ulrich  (2017) Outcome after resection of Adrenocortical Carcinoma liver metastases: a retrospective study.  BMC Cancer, 17 (522).  pp. 1-10.  ISSN 1471-2407     
document_url: https://archiv.ub.uni-heidelberg.de/volltextserver/23326/1/12885_2017_Article_3506.pdf