title: Diagnostic value of Pentraxin-3 in patients with sepsis and septic shock in accordance with latest sepsis-3 definitions
creator: Hamed, Sonja
creator: Behnes, Michael
creator: Pauly, Dominic
creator: Lepiorz, Dominic
creator: Barre, Max
creator: Becher, Tobias
creator: Lang, Siegfried
creator: Akin, Ibrahim
creator: Borggrefe, Martin
creator: Bertsch, Thomas
creator: Hoffmann, Ursula
subject: ddc-610
subject: 610 Medical sciences Medicine
description: Background: Pentraxin-3 (PTX-3) is an acute-phase protein involved in inflammatory and infectious processes. This study assesses its diagnostic and prognostic value in patients with sepsis or septic shock in a medical intensive care unit (ICU).   Methods: The study includes 213 ICU patients with clinical criteria of sepsis and septic shock. 77 donors served as controls. Plasma levels of PTX-3, procalcitonin (PCT) and interleukin-6 were measured on day 1, 3 and 8.   Results: PTX-3 correlated with higher lactate levels as well as with APACHE II and SOFA scores (p = 0.0001). PTX-3 levels of patients with sepsis or septic shock were consistently significantly higher than in the control group (p ≤ 0.001). Plasma levels were able to discriminate sepsis and septic shock significantly on day 1, 3 and 8 (range of AUC 0.73–0.92, p = 0.0001). Uniform cut-off levels were defined at ≥5 ng/ml for at least sepsis, ≥9 ng/ml for septic shock (p = 0.0001).   Conclusion: PTX-3 reveals diagnostic value for sepsis and septic shock during the first week of intensive care treatment, comparable to interleukin-6 according to latest Sepsis-3 definitions.   Trial registration: NCT01535534. Registered 14.02.2012
publisher: BioMed Central; Springer
date: 2017
type: Article
type: info:eu-repo/semantics/article
type: NonPeerReviewed
format: application/pdf
identifier: https://archiv.ub.uni-heidelberg.de/volltextserverhttps://archiv.ub.uni-heidelberg.de/volltextserver/23338/1/12879_2017_Article_2606.pdf
identifier: DOI:
identifier: urn:nbn:de:bsz:16-heidok-233387
identifier:   Hamed, Sonja ; Behnes, Michael ; Pauly, Dominic ; Lepiorz, Dominic ; Barre, Max ; Becher, Tobias ; Lang, Siegfried ; Akin, Ibrahim ; Borggrefe, Martin ; Bertsch, Thomas ; Hoffmann, Ursula  (2017) Diagnostic value of Pentraxin-3 in patients with sepsis and septic shock in accordance with latest sepsis-3 definitions.  BMC Infectious Diseases, 17 (554).  pp. 1-10.  ISSN 1471-2334     
relation: https://archiv.ub.uni-heidelberg.de/volltextserver/23338/
rights: info:eu-repo/semantics/openAccess
rights: Please see front page of the work (Sorry, Dublin Core plugin does not recognise license id)
language: eng