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primary topic: Diagnostic value of Pentraxin-3 in patients with sepsis and septic shock in accordance with latest sepsis-3 definitions

Diagnostic value of Pentraxin-3 in patients with sepsis and septic shock in accordance with latest sepsis-3 definitions
type: AcademicArticle
type: Article
abstract: Background: Pentraxin-3 (PTX-3) is an acute-phase protein involved in inflammatory and infectious processes. This study assesses its diagnostic and prognostic value in patients with sepsis or septic shock in a medical intensive care unit (ICU). Methods: The study includes 213 ICU patients with clinical criteria of sepsis and septic shock. 77 donors served as controls. Plasma levels of PTX-3, procalcitonin (PCT) and interleukin-6 were measured on day 1, 3 and 8. Results: PTX-3 correlated with higher lactate levels as well as with APACHE II and SOFA scores (p = 0.0001). PTX-3 levels of patients with sepsis or septic shock were consistently significantly higher than in the control group (p ≤ 0.001). Plasma levels were able to discriminate sepsis and septic shock significantly on day 1, 3 and 8 (range of AUC 0.73–0.92, p = 0.0001). Uniform cut-off levels were defined at ≥5 ng/ml for at least sepsis, ≥9 ng/ml for septic shock (p = 0.0001). Conclusion: PTX-3 reveals diagnostic value for sepsis and septic shock during the first week of intensive care treatment, comparable to interleukin-6 according to latest Sepsis-3 definitions. Trial registration: NCT01535534. Registered 14.02.2012
date: 2017
volume: 17
issue: 554
is part of: BMC Infectious Diseases
author list: authors
type: EPrint
type: ArticleEPrint
is part of: repository
has document: Diagnostic value of Pentraxin-3 in patients with sepsis and septic shock in accordance with latest sepsis-3 definitions (PDF)
has document: Diagnostic value of Pentraxin-3 in patients with sepsis and septic shock in accordance with latest sepsis-3 definitions (Other)
subject: 610 Medizin

Diagnostic value of Pentraxin-3 in patients with sepsis and septic shock in accordance with latest sepsis-3 definitions (PDF)
type: Document
has file: 12879_2017_Article_2606.pdf
has part: 12879_2017_Article_2606.pdf

BioMed Central; Springer
type: Organization

BMC Infectious Diseases
type: Collection
issn: 14712334

Ibrahim Akin
type: Person
given name: Ibrahim
family name: Akin

Dominic Pauly
type: Person
given name: Dominic
family name: Pauly

Martin Borggrefe
type: Person
given name: Martin
family name: Borggrefe

Michael Behnes
type: Person
given name: Michael
family name: Behnes

Siegfried Lang
type: Person
given name: Siegfried
family name: Lang

Ursula Hoffmann
type: Person
given name: Ursula
family name: Hoffmann

Tobias Becher
type: Person
given name: Tobias
family name: Becher

Thomas Bertsch
type: Person
given name: Thomas
family name: Bertsch

Max Barre
type: Person
given name: Max
family name: Barre

Dominic Lepiorz
type: Person
given name: Dominic
family name: Lepiorz

Sonja Hamed
type: Person
given name: Sonja
family name: Hamed

Diagnostic value of Pentraxin-3 in patients with sepsis and septic shock in accordance with latest sepsis-3 definitions (Other)
type: Document
is version of: Diagnostic value of Pentraxin-3 in patients with sepsis and septic shock in accordance with latest sepsis-3 definitions (PDF)
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Diagnostic value of Pentraxin-3 in patients with sepsis and septic shock in accordance with latest sepsis-3 definitions (Other)
type: Document
is version of: Diagnostic value of Pentraxin-3 in patients with sepsis and septic shock in accordance with latest sepsis-3 definitions (PDF)
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Diagnostic value of Pentraxin-3 in patients with sepsis and septic shock in accordance with latest sepsis-3 definitions (Other)
type: Document
is version of: Diagnostic value of Pentraxin-3 in patients with sepsis and septic shock in accordance with latest sepsis-3 definitions (PDF)
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Diagnostic value of Pentraxin-3 in patients with sepsis and septic shock in accordance with latest sepsis-3 definitions (Other)
type: Document
is version of: Diagnostic value of Pentraxin-3 in patients with sepsis and septic shock in accordance with latest sepsis-3 definitions (PDF)
is volatile version of: Diagnostic value of Pentraxin-3 in patients with sepsis and septic shock in accordance with latest sepsis-3 definitions (PDF)
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Diagnostic value of Pentraxin-3 in patients with sepsis and septic shock in accordance with latest sepsis-3 definitions (Other)
type: Document
is version of: Diagnostic value of Pentraxin-3 in patients with sepsis and septic shock in accordance with latest sepsis-3 definitions (PDF)
is volatile version of: Diagnostic value of Pentraxin-3 in patients with sepsis and septic shock in accordance with latest sepsis-3 definitions (PDF)
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HTML Summary of #23338 Diagnostic value of Pentraxin-3 in patients with sepsis and septic shock in accordance with latest sepsis-3 definitions
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primary topic: Diagnostic value of Pentraxin-3 in patients with sepsis and septic shock in accordance with latest sepsis-3 definitions

610 Medizin
type: Concept
preferred label: 610 Medical sciences Medicine @en