<> "The repository administrator has not yet configured an RDF license."^^ . <> . . . "Diagnostic value of Pentraxin-3 in patients with sepsis and septic shock in accordance with latest sepsis-3 definitions"^^ . "Background: Pentraxin-3 (PTX-3) is an acute-phase protein involved in inflammatory and infectious processes. This study assesses its diagnostic and prognostic value in patients with sepsis or septic shock in a medical intensive care unit (ICU). Methods: The study includes 213 ICU patients with clinical criteria of sepsis and septic shock. 77 donors served as controls. Plasma levels of PTX-3, procalcitonin (PCT) and interleukin-6 were measured on day 1, 3 and 8. Results: PTX-3 correlated with higher lactate levels as well as with APACHE II and SOFA scores (p = 0.0001). PTX-3 levels of patients with sepsis or septic shock were consistently significantly higher than in the control group (p ≤ 0.001). Plasma levels were able to discriminate sepsis and septic shock significantly on day 1, 3 and 8 (range of AUC 0.73–0.92, p = 0.0001). Uniform cut-off levels were defined at ≥5 ng/ml for at least sepsis, ≥9 ng/ml for septic shock (p = 0.0001). Conclusion: PTX-3 reveals diagnostic value for sepsis and septic shock during the first week of intensive care treatment, comparable to interleukin-6 according to latest Sepsis-3 definitions. Trial registration: NCT01535534. Registered 14.02.2012"^^ . "2017" . . "17" . "554" . . "BioMed Central; Springer"^^ . . . "BMC Infectious Diseases"^^ . . . "14712334" . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . "Ursula"^^ . "Hoffmann"^^ . "Ursula Hoffmann"^^ . . "Martin"^^ . "Borggrefe"^^ . "Martin Borggrefe"^^ . . "Dominic"^^ . "Lepiorz"^^ . "Dominic Lepiorz"^^ . . "Dominic"^^ . "Pauly"^^ . "Dominic Pauly"^^ . . "Max"^^ . "Barre"^^ . "Max Barre"^^ . . "Sonja"^^ . "Hamed"^^ . "Sonja Hamed"^^ . . "Siegfried"^^ . "Lang"^^ . "Siegfried Lang"^^ . . "Thomas"^^ . "Bertsch"^^ . "Thomas Bertsch"^^ . . "Ibrahim"^^ . "Akin"^^ . "Ibrahim Akin"^^ . . "Tobias"^^ . "Becher"^^ . "Tobias Becher"^^ . . "Michael"^^ . "Behnes"^^ . "Michael Behnes"^^ . . . . . . "Diagnostic value of Pentraxin-3 in patients with sepsis and septic shock in accordance with latest sepsis-3 definitions (PDF)"^^ . . . "12879_2017_Article_2606.pdf"^^ . . . "Diagnostic value of Pentraxin-3 in patients with sepsis and septic shock in accordance with latest sepsis-3 definitions (Other)"^^ . . . . . . "lightbox.jpg"^^ . . . "Diagnostic value of Pentraxin-3 in patients with sepsis and septic shock in accordance with latest sepsis-3 definitions (Other)"^^ . . . . . . "preview.jpg"^^ . . . "Diagnostic value of Pentraxin-3 in patients with sepsis and septic shock in accordance with latest sepsis-3 definitions (Other)"^^ . . . . . . "medium.jpg"^^ . . . "Diagnostic value of Pentraxin-3 in patients with sepsis and septic shock in accordance with latest sepsis-3 definitions (Other)"^^ . . . . . . "small.jpg"^^ . . . "Diagnostic value of Pentraxin-3 in patients with sepsis and septic shock in accordance with latest sepsis-3 definitions (Other)"^^ . . . . . . "indexcodes.txt"^^ . . "HTML Summary of #23338 \n\nDiagnostic value of Pentraxin-3 in patients with sepsis and septic shock in accordance with latest sepsis-3 definitions\n\n" . "text/html" . . . "610 Medizin"@de . "610 Medical sciences Medicine"@en . .