eprintid: 23338
rev_number: 12
eprint_status: archive
userid: 1589
dir: disk0/00/02/33/38
datestamp: 2017-08-15 12:40:26
lastmod: 2024-08-02 05:16:09
status_changed: 2017-08-15 12:40:26
type: article
metadata_visibility: show
creators_name: Hamed, Sonja
creators_name: Behnes, Michael
creators_name: Pauly, Dominic
creators_name: Lepiorz, Dominic
creators_name: Barre, Max
creators_name: Becher, Tobias
creators_name: Lang, Siegfried
creators_name: Akin, Ibrahim
creators_name: Borggrefe, Martin
creators_name: Bertsch, Thomas
creators_name: Hoffmann, Ursula
title: Diagnostic value of Pentraxin-3 in patients with sepsis and septic shock in accordance with latest sepsis-3 definitions
subjects: ddc-610
divisions: i-62100
divisions: i-62200
abstract: Background: Pentraxin-3 (PTX-3) is an acute-phase protein involved in inflammatory and infectious processes. This study assesses its diagnostic and prognostic value in patients with sepsis or septic shock in a medical intensive care unit (ICU).   Methods: The study includes 213 ICU patients with clinical criteria of sepsis and septic shock. 77 donors served as controls. Plasma levels of PTX-3, procalcitonin (PCT) and interleukin-6 were measured on day 1, 3 and 8.   Results: PTX-3 correlated with higher lactate levels as well as with APACHE II and SOFA scores (p = 0.0001). PTX-3 levels of patients with sepsis or septic shock were consistently significantly higher than in the control group (p ≤ 0.001). Plasma levels were able to discriminate sepsis and septic shock significantly on day 1, 3 and 8 (range of AUC 0.73–0.92, p = 0.0001). Uniform cut-off levels were defined at ≥5 ng/ml for at least sepsis, ≥9 ng/ml for septic shock (p = 0.0001).   Conclusion: PTX-3 reveals diagnostic value for sepsis and septic shock during the first week of intensive care treatment, comparable to interleukin-6 according to latest Sepsis-3 definitions.   Trial registration: NCT01535534. Registered 14.02.2012
date: 2017
publisher: BioMed Central; Springer
id_scheme: DOI
ppn_swb: 1654675970
own_urn: urn:nbn:de:bsz:16-heidok-233387
language: eng
bibsort: HAMEDSONJADIAGNOSTIC2017
full_text_status: public
publication: BMC Infectious Diseases
volume: 17
number: 554
place_of_pub: London; Berlin; Heidelberg
pagerange: 1-10
issn: 1471-2334
citation:   Hamed, Sonja ; Behnes, Michael ; Pauly, Dominic ; Lepiorz, Dominic ; Barre, Max ; Becher, Tobias ; Lang, Siegfried ; Akin, Ibrahim ; Borggrefe, Martin ; Bertsch, Thomas ; Hoffmann, Ursula  (2017) Diagnostic value of Pentraxin-3 in patients with sepsis and septic shock in accordance with latest sepsis-3 definitions.  BMC Infectious Diseases, 17 (554).  pp. 1-10.  ISSN 1471-2334     
document_url: https://archiv.ub.uni-heidelberg.de/volltextserver/23338/1/12879_2017_Article_2606.pdf