title: EMX2 gene expression predicts liver metastasis and survival in colorectal cancer
creator: Aykut, Berk
creator: Ochs, Markus
creator: Radhakrishnan, Praveen
creator: Brill, Adrian
creator: Höcker, Hermine
creator: Schwarz, Sandra
creator: Weissinger, Daniel
creator: Kehm, Roland
creator: Kulu, Yakup
creator: Ulrich, Alexis
creator: Schneider, Martin
subject: ddc-610
subject: 610 Medical sciences Medicine
description: Background: The Empty Spiracles Homeobox (EMX-) 2 gene has been associated with regulation of growth and differentiation in neuronal development. While recent studies provide evidence that EMX2 regulates tumorigenesis of various solid tumors, its role in colorectal cancer remains unknown. We aimed to assess the prognostic significance of EMX2 expression in stage III colorectal adenocarcinoma.   Methods: Expression levels of EMX2 in human colorectal cancer and adjacent mucosa were assessed by qRT-PCR technology, and results were correlated with clinical and survival data. siRNA-mediated knockdown and adenoviral delivery-mediated overexpression of EMX2 were performed in order to investigate its effects on the migration of colorectal cancer cells in vitro.   Results: Compared to corresponding healthy mucosa, colorectal tumor samples had decreased EMX2 expression levels. Furthermore, EMX2 down-regulation in colorectal cancer tissue was associated with distant metastasis (M1) and impaired overall patient survival. In vitro knockdown of EMX2 resulted in increased tumor cell migration. Conversely, overexpression of EMX2 led to an inhibition of tumor cell migration.   Conclusions: EMX2 is frequently down-regulated in human colorectal cancer, and down-regulation of EMX2 is a prognostic marker for disease-free and overall survival. EMX2 might thus represent a promising therapeutic target in colorectal cancer.
publisher: BioMed Central; Springer
date: 2017
type: Article
type: info:eu-repo/semantics/article
type: NonPeerReviewed
format: application/pdf
identifier: https://archiv.ub.uni-heidelberg.de/volltextserverhttps://archiv.ub.uni-heidelberg.de/volltextserver/23394/1/12885_2017_Article_3556.pdf
identifier: DOI:
identifier: urn:nbn:de:bsz:16-heidok-233945
identifier:   Aykut, Berk ; Ochs, Markus ; Radhakrishnan, Praveen ; Brill, Adrian ; Höcker, Hermine ; Schwarz, Sandra ; Weissinger, Daniel ; Kehm, Roland ; Kulu, Yakup ; Ulrich, Alexis ; Schneider, Martin  (2017) EMX2 gene expression predicts liver metastasis and survival in colorectal cancer.  BMC Cancer, 17 (555).  pp. 1-8.  ISSN 1471-2407     
relation: https://archiv.ub.uni-heidelberg.de/volltextserver/23394/
rights: info:eu-repo/semantics/openAccess
rights: Please see front page of the work (Sorry, Dublin Core plugin does not recognise license id)
language: eng