eprintid: 23395
rev_number: 11
eprint_status: archive
userid: 1589
dir: disk0/00/02/33/95
datestamp: 2017-09-05 09:00:10
lastmod: 2024-03-30 20:38:33
status_changed: 2017-09-05 09:00:10
type: article
metadata_visibility: show
creators_name: Giers, Bert C.
creators_name: Tandogan, Tamer
creators_name: Auffarth, Gerd U.
creators_name: Choi, Chul Y.
creators_name: Auerbach, Florian N.
creators_name: Sel, Saadettin
creators_name: Mayer, Christian
creators_name: Khoramnia, Ramin
title: Hydrophilic intraocular lens opacification after posterior lamellar keratoplasty - a material analysis with special reference to optical quality assessment
subjects: ddc-610
divisions: i-910900
abstract: Background: Laboratory analysis and optical quality assessment of explanted hydrophilic intraocular lenses (IOLs) with clinically significant opacification after posterior lamellar keratoplasty (DMEK and DSAEK).   Methods: Thirteen opacified IOLs after posterior lamellar keratoplasty, 8 after descemet stripping automated endothelial keratoplasty (DSAEK), 3 after descemet membrane endothelial keratoplasty (DMEK) and 2 after both DSAEK and DMEK were analysed in our laboratory. Analyses included optical bench assessment for optical quality, light microscopy, scanning electron microscopy (SEM) and energy dispersive X-Ray spectroscopy (EDS).   Results: In all IOLs the opacification was caused by a thin layer of calciumphosphate that had accumulated underneath the anterior optical surface of the IOLs in the area spared by the pupil/anterior capsulorhexis. The calcifications lead to a significant deterioration of the modulation transfer function across all spatial frequencies of the affected IOLs.   Conclusions: The instillation of exogenous material such as air or gas into the anterior chamber increases the risk for opacification of hydrophilic IOLs irrespective of the manufacturer or the exact composition of the hydrophilic lens material. It is recommended to avoid the use of hydrophilic acrylic IOLs in patients with endothelial dystrophy that will likely require procedures involving the intracameral instillation of air or gas, such as DMEK or DS(A)EK.
date: 2017
publisher: BioMed Central
id_scheme: DOI
ppn_swb: 1655673998
own_urn: urn:nbn:de:bsz:16-heidok-233958
language: eng
bibsort: GIERSBERTCHYDROPHILI2017
full_text_status: public
publication: BMC Ophthalmology
volume: 17
number: 150
place_of_pub: London
pagerange: 1-10
issn: 1471-2415
citation:   Giers, Bert C. ; Tandogan, Tamer ; Auffarth, Gerd U. ; Choi, Chul Y. ; Auerbach, Florian N. ; Sel, Saadettin ; Mayer, Christian ; Khoramnia, Ramin  (2017) Hydrophilic intraocular lens opacification after posterior lamellar keratoplasty - a material analysis with special reference to optical quality assessment.  BMC Ophthalmology, 17 (150).  pp. 1-10.  ISSN 1471-2415     
document_url: https://archiv.ub.uni-heidelberg.de/volltextserver/23395/1/12886_2017_Article_546.pdf