title: Cardiovascular risk in patients with alpha-1-antitrypsin deficiency
creator: Fähndrich, Sebastian
creator: Biertz, Frank
creator: Karch, Annika
creator: Kleibrink, Björn
creator: Koch, Armin
creator: Teschler, Helmut
creator: Welte, Tobias
creator: Kauczor, Hans-Ulrich
creator: Janciauskiene, Sabina
creator: Jörres, Rudolf A.
creator: Greulich, Timm
creator: Vogelmeier, Claus F.
creator: Bals, Robert
subject: ddc-610
subject: 610 Medical sciences Medicine
description: Background: Alpha-1-antitrypsin deficiency (AATD) is a rare inherited condition caused by mutations of the SERPINA1 gene that is associated with the development of a COPD like lung disease. The comorbidities in patients with AATD-related lung diseases are not well defined. The aim of this study was to analyze the clinical phenotype of AATD patients within the German COPD cohort study COSYCONET (“COPD and SYstemic consequences-COmorbidities NETwork”) cohort focusing on the distribution of comorbidities.   Method and results: The data from 2645 COSYCONET patients, including 139 AATD patients (110 with and 29 without augmentation therapy), were analyzed by descriptive statistics and regression analyses. We found significantly lower prevalence of cardiovascular comorbidities in AATD patients as compared to non-AATD COPD patients. After correction for age, pack years, body mass index, and sex, the differences were still significant for coronary artery disease (p = 0.002) and the prevalence of peripheral artery disease as determined by an ankle-brachial-index <= 0.9 (p = 0.035). Also the distribution of other comorbidities such as bronchiectasis differed between AATD and non-deficient COPD.   Conclusion: AATD is associated with a lower prevalence of cardiovascular disease, the underlying mechanisms need further investigation.
publisher: BioMed Central
date: 2017
type: Article
type: info:eu-repo/semantics/article
type: NonPeerReviewed
format: application/pdf
identifier: https://archiv.ub.uni-heidelberg.de/volltextserver/23499/1/12931_2017_Article_655.pdf
identifier: DOI:
identifier: urn:nbn:de:bsz:16-heidok-234991
identifier:   Fähndrich, Sebastian ; Biertz, Frank ; Karch, Annika ; Kleibrink, Björn ; Koch, Armin ; Teschler, Helmut ; Welte, Tobias ; Kauczor, Hans-Ulrich ; Janciauskiene, Sabina ; Jörres, Rudolf A. ; Greulich, Timm ; Vogelmeier, Claus F. ; Bals, Robert  (2017) Cardiovascular risk in patients with alpha-1-antitrypsin deficiency.  Respiratory Research, 18 (171).  pp. 1-11.  ISSN 1465-993X     
relation: https://archiv.ub.uni-heidelberg.de/volltextserver/23499/
rights: info:eu-repo/semantics/openAccess
rights: Please see front page of the work (Sorry, Dublin Core plugin does not recognise license id)
language: eng