eprintid: 23644
rev_number: 15
eprint_status: archive
userid: 1589
dir: disk0/00/02/36/44
datestamp: 2017-10-24 08:32:08
lastmod: 2024-03-27 05:21:39
status_changed: 2017-10-24 08:32:08
type: article
metadata_visibility: show
creators_name: Polke, Markus
creators_name: Oelmann-Avendaño, Jan
creators_name: Warth, Arne
creators_name: Heussel, Claus-Peter
creators_name: Herth, Felix J. F.
creators_name: Eberhardt, Ralf
title: Successful treatment of a recurrent granulation polyp in the airways with high-dose-rate brachytherapy: a case report
subjects: 610
divisions: 910100
divisions: 911400
divisions: 912000
divisions: 942000
abstract: Background Benign central airway tumors are very rare diseases. Their unspecific symptoms are responsible for late diagnosis. Endoscopic interventions with different techniques and tools are widely used for their treatment. However, in certain cases interventional endoscopy might be unsuccessful and therefore other methods such as high-dose-rate brachytherapy could be a therapeutic option.   Case presentation A 76-year-old white German woman was referred to our clinic for an endoscopic treatment of a recurrent granulation polyp in her left main bronchus. She had dyspnea, coughing, and mucus retention. Three times resections via bronchoscopy were performed within less than a year. After each intervention the polyp regrew inside her left main bronchus causing a repeat of the initial symptoms. She presented to our clinic less than 1 month since the last intervention. Twice we performed a rigid bronchoscopy in total anesthesia where we resected the granulation polyp with a snare wire loop and did an argon plasma coagulation of its base. Due to the recurrent growing of the granuloma, we performed a high-dose-rate brachytherapy in conscious sedation after another interventional bronchoscopy with a resection of the polyp and argon plasma coagulation of the base. Three months after brachytherapy our patient came to our clinic for a follow-up with none of the initial symptoms. Only a small remnant of the polyp without a significant occlusion of her bronchus was visualized by bronchoscopy. Furthermore, 6 months after brachytherapy she was not presenting any of the initial symptoms.   Conclusions This case report shows that high-dose-rate brachytherapy is a therapeutic option for the treatment of benign airway stenosis when other interventional treatments are not or are less than successful. However, further investigations are needed to prove the effectiveness and reliability of the method.
date: 2017
publisher: BioMed Central
id_scheme: DOI
ppn_swb: 1657164314
own_urn: urn:nbn:de:bsz:16-heidok-236445
language: eng
bibsort: POLKEMARKUSUCCESSFUL2017
full_text_status: public
publication: Journal of medical case reports
volume: 11
number: 289
place_of_pub: London
pagerange: 1-5
issn: 1752-1947
citation:   Polke, Markus ; Oelmann-Avendaño, Jan ; Warth, Arne ; Heussel, Claus-Peter ; Herth, Felix J. F. ; Eberhardt, Ralf  (2017) Successful treatment of a recurrent granulation polyp in the airways with high-dose-rate brachytherapy: a case report.  Journal of medical case reports, 11 (289).  pp. 1-5.  ISSN 1752-1947     
document_url: https://archiv.ub.uni-heidelberg.de/volltextserver/23644/1/13256_2017_Article_1465.pdf