<> "The repository administrator has not yet configured an RDF license."^^ . <> . . "Metabolic Profiling of Cancer Cells and Correlations\r\nbetween Metabolism, Gene Expression and Drug Sensitivity"^^ . "Detailed\r\nmetabolic\r\ncharacterization\r\nof\r\ncancer\r\ncells\r\nprovides\r\nan\r\nimportant\r\ncellular\r\nfootprint\r\nin\r\naddition\r\nto\r\nwell-­‐studied\r\ngenomic\r\nfeatures\r\nand\r\ncould\r\nplay\r\nan\r\nimportant\r\nrole\r\nfor\r\nunderstanding\r\nsensitivity\r\nof\r\ncancer\r\ncells\r\nto\r\ndrug\r\ntreatment.\r\nThus,\r\ndetailed\r\nunderstanding\r\nof\r\nmetabolism\r\nand\r\ngene\r\nexpression\r\nprofiles\r\nof\r\ncancer\r\ncells\r\ncould\r\nbe\r\nan\r\nimportant\r\nguideline\r\nsupporting\r\nthe\r\nsteps\r\nof\r\ndrug\r\nselection\r\nand\r\na\r\ndetermining\r\nfactor\r\nfor\r\ndesigning\r\ntreatment\r\nstrategies\r\nwith\r\navailable\r\nanticancer\r\ndrugs.\r\nThe\r\naim\r\nof\r\nthe\r\npresented\r\nstudy\r\nwas\r\nto\r\nanalyze\r\nthe\r\nmetabolic\r\nactivities\r\nand\r\ncell-­‐cell\r\ninteraction\r\nand\r\ncell-­‐matrix\r\nadhesion\r\nproperties\r\nof\r\na\r\nlarge\r\nnumber\r\nof\r\ncancer\r\ncell\r\nlines\r\nand\r\ncorrelate\r\nthese\r\ncellular\r\ncharacteristics\r\nwith\r\ndrug\r\nsensitivity\r\nand\r\ncompare\r\nthis\r\nrelation\r\nto\r\nestablished\r\nknowledge\r\nusing\r\ngene\r\nexpression\r\nand\r\ndrug\r\nsensitivity\r\nprediction.\r\nFor\r\nthis,\r\ncorrelations\r\namong\r\nthese\r\ndifferent\r\nset\r\nof\r\nanalytical\r\ninformation\r\nwere\r\nanalyzed\r\nto\r\nobtain\r\ncancer\r\ncell\r\nprofiles\r\nlinking\r\nmetabolism,\r\ngene\r\nexpression\r\nand\r\ndrug\r\nIC50\r\nvalues,\r\nby\r\ncalculating\r\nPearson\r\ncorrelation\r\ncoefficients.\r\nThe\r\nresults\r\nobtained\r\nclearly\r\ncorroborate\r\nwell-­‐known\r\nrelations\r\nbut\r\nalso\r\nprovide\r\nimportant\r\nnovel\r\nfindings\r\nunderlying\r\nthe\r\nimportance\r\nof\r\ncancer\r\ncell\r\nmetabolism\r\nin\r\ndrug\r\nsensitivity.\r\nAs\r\nexpected,\r\nthe\r\nproliferation\r\nrate\r\ncorrelates\r\nwell\r\nwith\r\nthe\r\nglycolytic\r\nactivity\r\nof\r\ncancer\r\ncells\r\n(r\r\n=\r\n0.71**)\r\nas\r\nwell\r\nas\r\nwith\r\nHOXA7\r\nexpression\r\n(r\r\n=\r\n0.95***).\r\nThe\r\nmetabolism-­‐related\r\ncandidate\r\ngenes\r\nare\r\nPGLS,\r\nCOX5B,\r\nRHBDL2,\r\nIFI16,\r\nGCN1L1,\r\nINPP5B,\r\nand\r\nLGALS8.\r\nFurthermore,\r\nthe\r\ncalculated\r\nPearson\r\nproduct-­‐moment\r\ncorrelation\r\ncoefficients\r\nshow\r\nthat\r\nthe\r\nsensitivity\r\nof\r\nseven\r\nknown\r\ndrugs\r\ncorrelate\r\nwith\r\nsome\r\nof\r\nthe\r\nanalyzed\r\ncellular\r\nfeatures\r\nof\r\ncancer\r\ncells.\r\nThese\r\ncompounds\r\nare\r\nelesclomol,\r\nNutlin\r\n3a,\r\nPF\r\n4708671,\r\nEHT\r\n1864,\r\nIPA3,\r\nRDEA119,\r\nand\r\nmethotrexate.\r\nThe\r\ndetailed\r\nmetabolic\r\nand\r\nelectrochemical\r\nprofiling\r\nof\r\ncancer\r\ncells\r\ncarried\r\nout\r\nfor\r\nthis\r\nstudy\r\nreveals\r\nnew\r\nrelationships\r\nbetween\r\ngenes\r\nexpression,\r\ndrug\r\nsensitivity/tolerance,\r\nand\r\nbasic\r\nmetabolic\r\nfeatures\r\nof\r\ncancer\r\ncells.\r\nNew\r\ninsights\r\nare\r\nprovided\r\ninto\r\ncancer\r\nmetabolism,\r\ngenomic\r\nregulation,\r\nand\r\na\r\npotential\r\napplication\r\nto\r\ndesigning\r\nnew\r\nchemotherapeutic\r\nstrategies."^^ . "2018" . . . . . . . "Mariela"^^ . "Huichalaf Carbonell"^^ . "Mariela Huichalaf Carbonell"^^ . . . . . . "Metabolic Profiling of Cancer Cells and Correlations\r\nbetween Metabolism, Gene Expression and Drug Sensitivity (PDF)"^^ . . . "Huichalaf Dissertation.pdf"^^ . . . "Metabolic Profiling of Cancer Cells and Correlations\r\nbetween Metabolism, Gene Expression and Drug Sensitivity (Other)"^^ . . . . . . "indexcodes.txt"^^ . . . "Metabolic Profiling of Cancer Cells and Correlations\r\nbetween Metabolism, Gene Expression and Drug Sensitivity (Other)"^^ . . . . . . "lightbox.jpg"^^ . . . "Metabolic Profiling of Cancer Cells and Correlations\r\nbetween Metabolism, Gene Expression and Drug Sensitivity (Other)"^^ . . . . . . "preview.jpg"^^ . . . "Metabolic Profiling of Cancer Cells and Correlations\r\nbetween Metabolism, Gene Expression and Drug Sensitivity (Other)"^^ . . . . . . "medium.jpg"^^ . . . "Metabolic Profiling of Cancer Cells and Correlations\r\nbetween Metabolism, Gene Expression and Drug Sensitivity (Other)"^^ . . . . . . "small.jpg"^^ . . "HTML Summary of #23724 \n\nMetabolic Profiling of Cancer Cells and Correlations \nbetween Metabolism, Gene Expression and Drug Sensitivity\n\n" . "text/html" . .