<> "The repository administrator has not yet configured an RDF license."^^ . <> . . "HECATE factors control cell fate transitions and organ\r\npatterning in Arabidopsis thaliana"^^ . "Throughout their life span, plants keep the ability to generate new tissues and\r\norgans. This remarkable developmental property relies on the continuous activity of\r\npluripotent stem cells localized in meristems, which generate cell progenies acquiring\r\nspecific cellular identities. Thus, the regulatory processes controlling the progression\r\nof stem cell lineages and their final differentiation are essential to establish the whole\r\nbody plan and to ultimately define plant reproductive success. The integration of\r\nphytohormonal signals like auxin or cytokinin with key transcriptional regulators is\r\ncentral for balancing stem cell activity and differentiation (reviewed in Gaillochet and\r\nLohmann, 2015), however our current understanding of the regulatory interactions\r\nmediating this molecular communication remains elusive.\r\nIn this study, we used an integrated approach–including live-cell imaging,\r\ncomputational modeling, genome-wide profiling and genetic functional\r\ncharacterization–to investigate the function of the bHLH transcription factors\r\nHECATE (HEC) in controlling stem cell homeostasis and organ patterning. We found\r\nthat HEC regulatory function is highly versatile and tightly interacts with cytokinin and\r\nauxin signalling pathways under multiple developmental contexts. We show in the\r\nshoot apical meristem that HEC function regulates the timing of stem cell\r\ndifferentiation by locally promoting cytokinin at the centre of the meristem and\r\nrepressing auxin signals at the periphery. In contrast, we found that HEC genes\r\npattern style differentiation at the gynoecium by regulating auxin flow and by\r\nbuffering cytokinin responses. Using a gene network reconstruction approach, we\r\nstarted to unravel the regulatory interactions mediating HEC functional versatility and\r\nidentified NGATHA transcription factors as relevant direct targets controlling shoot\r\nmeristem activity. Together, our findings refine the molecular and developmental\r\nframework for shoot meristem activity and gynoecium differentiation."^^ . "2017" . . . . . . . "Christophe"^^ . "Gaillochet"^^ . "Christophe Gaillochet"^^ . . . . . . "HECATE factors control cell fate transitions and organ\r\npatterning in Arabidopsis thaliana (PDF)"^^ . . . "Gaillochet_thesis_2017_V3.pdf"^^ . . . "HECATE factors control cell fate transitions and organ\r\npatterning in Arabidopsis thaliana (Other)"^^ . . . . . . "indexcodes.txt"^^ . . . "HECATE factors control cell fate transitions and organ\r\npatterning in Arabidopsis thaliana (Other)"^^ . . . . . . "lightbox.jpg"^^ . . . "HECATE factors control cell fate transitions and organ\r\npatterning in Arabidopsis thaliana (Other)"^^ . . . . . . "preview.jpg"^^ . . . "HECATE factors control cell fate transitions and organ\r\npatterning in Arabidopsis thaliana (Other)"^^ . . . . . . "medium.jpg"^^ . . . "HECATE factors control cell fate transitions and organ\r\npatterning in Arabidopsis thaliana (Other)"^^ . . . . . . "small.jpg"^^ . . "HTML Summary of #23794 \n\nHECATE factors control cell fate transitions and organ \npatterning in Arabidopsis thaliana\n\n" . "text/html" . . . "570 Biowissenschaften, Biologie"@de . "570 Life sciences"@en . .