<> "The repository administrator has not yet configured an RDF license."^^ . <> . . "Molecular characterization of public anti-PfCSP antibodies in human malaria"^^ . "Plasmodium falciparum is a unicellular parasite that throughout its complex lifecycle infects Anopheles\r\nmosquitos and humans. The parasite stages injected into the human by the mosquito are called\r\nsporozoites and can be neutralized by antibodies generated by the human immune system. The\r\npresent study investigates the humoral immune response, i.e. the antibody response, to the major\r\nantigen on the sporozoite surface, circumsporozoite protein (CSP).\r\nA recently published study describes high-affine anti-CSP antibodies, which are generated upon\r\nrepeated controlled human malaria infection of European donors, who were never exposed to the\r\nparasite before. The present work on the one hand describes the molecular characteristics that\r\ndetermine the binding of such antibodies. On the other hand, it investigates whether African donors\r\nfrom an endemic malaria region exhibited similar antibodies.\r\nIn the repertoire of the European donors, several groups of antibodies were identified that share\r\nhighly similar amino acid sequences and binding behaviours. It is shown that these antibodies can\r\nonly bind to the antigen if very specific sequence characteristics are conserved. This probably restricts\r\nthe number of potential B cell precursors that can lead to the generation of such antibodies. The\r\nmost important result of this study is the observation that antibodies binding the repetitive region\r\nof CSP directly interact with each other. The antibodies even show signs of anti-idiotope affinity\r\nmaturation directed against the antigen binding site of neighbouring antibodies. Surprisingly in none\r\nof the three probed African donors antibodies with measurable anti-CSP reactivity could be found.\r\nThe present work suggests that this is due to the low frequency of B cell precursors, but also due\r\nto the specific binding mode that is induced by the repetitive CSP structure."^^ . "2019" . . . . . . . "Katharina Christina"^^ . "Imkeller"^^ . "Katharina Christina Imkeller"^^ . . . . . . "Molecular characterization of public anti-PfCSP antibodies in human malaria (PDF)"^^ . . . "thesis_katharina_imkeller.pdf"^^ . . . "Molecular characterization of public anti-PfCSP antibodies in human malaria (Other)"^^ . . . . . . "indexcodes.txt"^^ . . . "Molecular characterization of public anti-PfCSP antibodies in human malaria (Other)"^^ . . . . . . "lightbox.jpg"^^ . . . "Molecular characterization of public anti-PfCSP antibodies in human malaria (Other)"^^ . . . . . . "preview.jpg"^^ . . . "Molecular characterization of public anti-PfCSP antibodies in human malaria (Other)"^^ . . . . . . "medium.jpg"^^ . . . "Molecular characterization of public anti-PfCSP antibodies in human malaria (Other)"^^ . . . . . . "small.jpg"^^ . . "HTML Summary of #24239 \n\nMolecular characterization of public anti-PfCSP antibodies in human malaria\n\n" . "text/html" . . . "570 Biowissenschaften, Biologie"@de . "570 Life sciences"@en . .