%0 Journal Article
%@ 2047-783X
%A Rusnak, Jonas
%A Behnes, Michael
%A Henzler, Thomas
%A Reckord, Nadine
%A Vogler, Nils
%A Meyer, Mathias
%A Hoffmann, Ursula
%A Natale, Michele
%A Hoffmann, Julia
%A Hamed, Sonja
%A Weidner, Kathrin
%A Lang, Siegfried
%A Mukherji, Agnibh
%A Haubenreisser, Holger
%A Schoenberg, Stefan O.
%A Borggrefe, Martin
%A Bertsch, Thomas
%A Akin, Ibrahim
%C London ; Munich
%D 2017
%F heidok:24250
%I BioMed Central ; Holzapfel
%J European journal of medical research
%N 47
%P 1-9
%T Comparative analysis of high-sensitivity cardiac troponin I and T for their association with coronary computed tomography-assessed calcium scoring represented by the Agatston score
%U https://archiv.ub.uni-heidelberg.de/volltextserver/24250/
%V 22
%X Background: This study evaluates the association between high-sensitivity cardiac troponin I (hs-cTnI) and T (hs-cTnT) and coronary calcium concentration (CAC) detected by coronary computed tomography (CCT) and evaluated with the Agatston score in patients with suspected coronary artery disease (CAD).       Methods: Patients undergoing CCT during routine clinical care were enrolled prospectively. CCT was indicated for patients with a low to intermediate pretest probability for CAD. Within 24 h of CCT examination, peripheral blood samples were taken to measure cardiac biomarkers hs-cTnI and hs-cTnT.       Results: A total of 76 patients were enrolled including 38% without detectable CAC, 36% with an Agatston score from 1 to 100, 17% from 101 to 400, and 9% with values ≥ 400. hs-cTnI was increasing alongside Agatston score and was able to differentiate between different groups of Agatston scores. Both hs-cTn discriminated values greater than 100 (hs-cTnI, AUC = 0.663; p = 0.032; hs-cTnT, AUC = 0.650; p = 0.048). In univariate and multivariate logistic regression models, hs-cTnT and hs-cTnI were significantly associated with increased Agatston scores. Patients with hs-cTnT ≥ 0.02 µg/l and hs-cTnI ≥ 5.5 ng/l were more likely to reveal values ≥ 400 (hs-cTnT; OR = 13.4; 95% CI 1.545–116.233; p = 0.019; hs-cTnI; OR = 8.8; 95% CI 1.183–65.475; p = 0.034).       Conclusion: The present study shows that the Agatston score was significantly correlated with hs cardiac troponins, both in univariable and multivariable linear regression models. Hs-cTnI is able to discriminate between different Agatston values. The present results might reveal potential cut-off values for hs cardiac troponins regarding different Agatston values.      Trial registration Cardiovascular Imaging and Biomarker Analyses (CIBER), NCT03074253 https://clinicaltrials.gov/ct2/show/record/NCT03074253