<> "The repository administrator has not yet configured an RDF license."^^ . <> . . . "Comparative analysis of high-sensitivity cardiac troponin I and T for their association with coronary computed tomography-assessed calcium scoring represented by the Agatston score"^^ . "Background: This study evaluates the association between high-sensitivity cardiac troponin I (hs-cTnI) and T (hs-cTnT) and coronary calcium concentration (CAC) detected by coronary computed tomography (CCT) and evaluated with the Agatston score in patients with suspected coronary artery disease (CAD).\r\n \r\nMethods: Patients undergoing CCT during routine clinical care were enrolled prospectively. CCT was indicated for patients with a low to intermediate pretest probability for CAD. Within 24 h of CCT examination, peripheral blood samples were taken to measure cardiac biomarkers hs-cTnI and hs-cTnT. \r\n \r\nResults: A total of 76 patients were enrolled including 38% without detectable CAC, 36% with an Agatston score from 1 to 100, 17% from 101 to 400, and 9% with values ≥ 400. hs-cTnI was increasing alongside Agatston score and was able to differentiate between different groups of Agatston scores. Both hs-cTn discriminated values greater than 100 (hs-cTnI, AUC = 0.663; p = 0.032; hs-cTnT, AUC = 0.650; p = 0.048). In univariate and multivariate logistic regression models, hs-cTnT and hs-cTnI were significantly associated with increased Agatston scores. Patients with hs-cTnT ≥ 0.02 µg/l and hs-cTnI ≥ 5.5 ng/l were more likely to reveal values ≥ 400 (hs-cTnT; OR = 13.4; 95% CI 1.545–116.233; p = 0.019; hs-cTnI; OR = 8.8; 95% CI 1.183–65.475; p = 0.034). \r\n\r\nConclusion: The present study shows that the Agatston score was significantly correlated with hs cardiac troponins, both in univariable and multivariable linear regression models. Hs-cTnI is able to discriminate between different Agatston values. The present results might reveal potential cut-off values for hs cardiac troponins regarding different Agatston values. \r\n\r\nTrial registration Cardiovascular Imaging and Biomarker Analyses (CIBER), NCT03074253 https://clinicaltrials.gov/ct2/show/record/NCT03074253"^^ . "2017" . . "22" . "47" . . "BioMed Central ; Holzapfel"^^ . . . "European journal of medical research"^^ . . . "2047783X" . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . "Jonas"^^ . "Rusnak"^^ . "Jonas Rusnak"^^ . . "Michele"^^ . "Natale"^^ . "Michele Natale"^^ . . "Agnibh"^^ . "Mukherji"^^ . "Agnibh Mukherji"^^ . . "Thomas"^^ . "Bertsch"^^ . "Thomas Bertsch"^^ . . "Siegfried"^^ . "Lang"^^ . "Siegfried Lang"^^ . . "Michael"^^ . "Behnes"^^ . "Michael Behnes"^^ . . "Ursula"^^ . "Hoffmann"^^ . "Ursula Hoffmann"^^ . . "Sonja"^^ . "Hamed"^^ . "Sonja Hamed"^^ . . "Ibrahim"^^ . "Akin"^^ . "Ibrahim Akin"^^ . . "Kathrin"^^ . "Weidner"^^ . "Kathrin Weidner"^^ . . "Holger"^^ . "Haubenreisser"^^ . "Holger Haubenreisser"^^ . . "Mathias"^^ . "Meyer"^^ . "Mathias Meyer"^^ . . "Julia"^^ . "Hoffmann"^^ . "Julia Hoffmann"^^ . . "Nadine"^^ . "Reckord"^^ . "Nadine Reckord"^^ . . "Thomas"^^ . "Henzler"^^ . "Thomas Henzler"^^ . . "Stefan O."^^ . "Schoenberg"^^ . "Stefan O. Schoenberg"^^ . . "Martin"^^ . "Borggrefe"^^ . "Martin Borggrefe"^^ . . "Nils"^^ . "Vogler"^^ . "Nils Vogler"^^ . . . . . . "Comparative analysis of high-sensitivity cardiac troponin I and T for their association with coronary computed tomography-assessed calcium scoring represented by the Agatston score (Other)"^^ . . . . . . "medium.jpg"^^ . . . "Comparative analysis of high-sensitivity cardiac troponin I and T for their association with coronary computed tomography-assessed calcium scoring represented by the Agatston score (Other)"^^ . . . . . . "small.jpg"^^ . . . "Comparative analysis of high-sensitivity cardiac troponin I and T for their association with coronary computed tomography-assessed calcium scoring represented by the Agatston score (PDF)"^^ . . . "40001_2017_Article_290.pdf"^^ . . . "Comparative analysis of high-sensitivity cardiac troponin I and T for their association with coronary computed tomography-assessed calcium scoring represented by the Agatston score (Other)"^^ . . . . . . "indexcodes.txt"^^ . . . "Comparative analysis of high-sensitivity cardiac troponin I and T for their association with coronary computed tomography-assessed calcium scoring represented by the Agatston score (Other)"^^ . . . . . . "lightbox.jpg"^^ . . . "Comparative analysis of high-sensitivity cardiac troponin I and T for their association with coronary computed tomography-assessed calcium scoring represented by the Agatston score (Other)"^^ . . . . . . "preview.jpg"^^ . . "HTML Summary of #24250 \n\nComparative analysis of high-sensitivity cardiac troponin I and T for their association with coronary computed tomography-assessed calcium scoring represented by the Agatston score\n\n" . "text/html" . . . "610 Medizin"@de . "610 Medical sciences Medicine"@en . .