eprintid: 24268
rev_number: 13
eprint_status: archive
userid: 1589
dir: disk0/00/02/42/68
datestamp: 2018-04-18 09:49:10
lastmod: 2024-04-09 06:30:18
status_changed: 2018-04-18 09:49:10
type: article
metadata_visibility: show
creators_name: Bischoff, Sebastian
creators_name: Walter, Thomas
creators_name: Gerigk, Marlis
creators_name: Ebert, Matthias
creators_name: Vogelmann, Roger
title: Empiric antibiotic therapy in urinary tract infection in patients with risk factors for antibiotic resistance in a German emergency department
subjects: ddc-610
divisions: i-62300
abstract: Background: The aim of this study was to identify clinical risk factors for antimicrobial resistances and multidrug resistance (MDR) in urinary tract infections (UTI) in an emergency department in order to improve empirical therapy.

Methods: UTI cases from an emergency department (ED) during January 2013 and June 2015 were analyzed. Differences between patients with and without resistances towards Ciprofloxacin, Piperacillin with Tazobactam (Pip/taz), Gentamicin, Cefuroxime, Cefpodoxime and Ceftazidime were analyzed with Fisher’s exact tests. Results were used to identify risk factors with logistic regression modelling. Susceptibility rates were analyzed in relation to risk factors.

Results: One hundred thirty-seven of four hundred sixty-nine patients who met the criteria of UTI had a positive urine culture. An MDR pathogen was found in 36.5% of these. Overall susceptibility was less than 85% for standard antimicrobial agents. Logistic regression identified residence in nursing homes, male gender, hospitalization within the last 30 days, renal transplantation, antibiotic treatment within the last 30 days, indwelling urinary catheter and recurrent UTI as risk factors for MDR or any of these resistances. For patients with no risk factors Ciprofloxacin had 90%, Pip/taz 88%, Gentamicin 95%, Cefuroxime 98%, Cefpodoxime 98% and Ceftazidime 100% susceptibility. For patients with 1 risk factor Ciprofloxacin had 80%, Pip/taz 80%, Gentamicin 88%, Cefuroxime 78%, Cefpodoxime 78% and Ceftazidime 83% susceptibility. For 2 or more risk factors Ciprofloxacin drops its susceptibility to 52%, Cefuroxime to 54% and Cefpodoxime to 61%. Pip/taz, Gentamicin and Ceftazidime remain at 75% and 77%, respectively.

Conclusions: We identified several risk factors for resistances and MDR in UTI. Susceptibility towards antimicrobials depends on these risk factors. With no risk factor cephalosporins seem to be the best choice for empiric therapy, but in patients with risk factors the beta-lactam penicillin Piperacillin with Tazobactam is an equal or better choice compared to fluoroquinolones, cephalosporins or gentamicin. This study highlights the importance of monitoring local resistance rates and its risk factors in order to improve empiric therapy in a local environment.
date: 2018
publisher: BioMed Central ; Springer
id_scheme: DOI
ppn_swb: 1656463024
own_urn: urn:nbn:de:bsz:16-heidok-242684
language: eng
bibsort: BISCHOFFSEEMPIRICANT2018
full_text_status: public
publication: BMC Infectious Diseases
volume: 18
number: 56
place_of_pub: London ; Berlin ; Heidelberg
pagerange: 1-7
issn: 1471-2334
citation:   Bischoff, Sebastian ; Walter, Thomas ; Gerigk, Marlis ; Ebert, Matthias ; Vogelmann, Roger  (2018) Empiric antibiotic therapy in urinary tract infection in patients with risk factors for antibiotic resistance in a German emergency department.  BMC Infectious Diseases, 18 (56).  pp. 1-7.  ISSN 1471-2334     
document_url: https://archiv.ub.uni-heidelberg.de/volltextserver/24268/1/12879_2018_Article_2960.pdf