title: EnrichedHeatmap: an R/Bioconductor package for comprehensive visualization of genomic signal associations
creator: Gu, Zuguang
creator: Eils, Roland
creator: Schlesner, Matthias
creator: Ishaque, Naveed
subject: 570
subject: 570 Life sciences
subject: 610
subject: 610 Medical sciences Medicine
description: Background: High-throughput sequencing data are dramatically increasing in volume. Thus, there is urgent need for efficient tools to perform fast and integrative analysis of multiple data types. Enriched heatmap is a specific form of heatmap that visualizes how genomic signals are enriched over specific target regions. It is commonly used and efficient at revealing enrichment patterns especially for high dimensional genomic and epigenomic datasets.    Results: We present a new R package named EnrichedHeatmap that efficiently visualizes genomic signal enrichment. It provides advanced solutions for normalizing genomic signals within target regions as well as offering highly customizable visualizations. The major advantage of EnrichedHeatmap is the ability to conveniently generate parallel heatmaps as well as complex annotations, which makes it easy to integrate and visualize comprehensive  overviews of the patterns and associations within and between complex datasets.    Conclusions: EnrichedHeatmap facilitates comprehensive understanding of high dimensional genomic and epigenomic data. The power of EnrichedHeatmap is demonstrated by visualization of the complex associations between DNA methylation, gene expression and various histone modifications.
publisher: BioMed Central ; Springer
date: 2018
type: Article
type: info:eu-repo/semantics/article
type: NonPeerReviewed
format: application/pdf
identifier: https://archiv.ub.uni-heidelberg.de/volltextserverhttps://archiv.ub.uni-heidelberg.de/volltextserver/24271/1/12864_2018_Article_4625.pdf
identifier: DOI:https://doi.org/10.1186/s12864-018-4625-x
identifier: urn:nbn:de:bsz:16-heidok-242714
identifier:   Gu, Zuguang ; Eils, Roland ; Schlesner, Matthias ; Ishaque, Naveed  (2018) EnrichedHeatmap: an R/Bioconductor package for comprehensive visualization of genomic signal associations.  BMC Genomics, 19 (234).  pp. 2-7.  ISSN 1471-2164     
relation: https://archiv.ub.uni-heidelberg.de/volltextserver/24271/
rights: info:eu-repo/semantics/openAccess
rights: Please see front page of the work (Sorry, Dublin Core plugin does not recognise license id)
language: eng