eprintid: 24274
rev_number: 14
eprint_status: archive
userid: 1589
dir: disk0/00/02/42/74
datestamp: 2018-05-30 08:44:07
lastmod: 2024-05-16 03:28:43
status_changed: 2018-05-30 08:44:07
type: article
metadata_visibility: show
creators_name: Ressing, Meike
creators_name: Wardelmann, Eva
creators_name: Hohenberger, Peter
creators_name: Jakob, Jens
creators_name: Kasper, Bernd
creators_name: Emrich, Katharina
creators_name: Eberle, Andrea
creators_name: Blettner, Maria
creators_name: Zeissig, Sylke R.
title: Strengthening health data on a rare and heterogeneous disease: sarcoma incidence and histological subtypes in Germany
subjects: ddc-610
divisions: i-999803
abstract: Background: The population-based incidence of sarcoma and its histological subtypes in Germany is unknown. Up-to-date information on a disease with an incidence comparable to other cancer entities is of high public health relevance. The aim of this study was to determine this incidence and to detect significant changes in incidence trends using data from German epidemiological cancer registries.

Methods: Pooled data from the German Centre for Cancer Registry Data with a primary diagnosis occurring in 2013 were used. To date, this is the latest data on cancer incidence available for Germany. All German cancer registries with sufficient completeness were included (10 out of 11), covering a population of 70.0 million people, representing 87% of the German population. All malignant sarcomas according to the RARECARE Project and the WHO classification 2002 were considered for analysis and, above all, gastrointestinal stromal tumours (GIST) of uncertain behaviour. Sensitivity analysis was performed excluding certain histologies.   

Results: The analysis included 3404 cases in men and 3442 cases in women diagnosed in 2013. The age adjusted sarcoma incidence (European standard) was 7.4 (men) and 6.6 (women) per 100,000 inhabitants. About 70% of sarcomas were soft tissue sarcomas, about 22% GIST, and about 9% bone sarcomas. The most common histological subtypes besides GIST were fibrosarcomas (14%) and liposarcomas (12%) in men and complex mixed and stromal neoplasms (22%), non-uterine leiomysarcomas (10%) and fibrosarcomas (9%) in women. Considering the trend for the years of diagnosis 2004 to 2013, there was a significant increase in incidence for GIST while the incidence of soft tissue sarcomas (only men) as well as of bone sarcoma stayed constant over time. As to soft tissue sarcoma in women, the incidence stayed constant up to the year 2009 and significantly decreased afterwards.

Conclusion: This study is the first detailed analysis of a German-wide population-based sarcoma incidence showing results comparable to the incidence detected in the RARECARE Project.
date: 2018
publisher: BioMed Central
id_scheme: DOI
ppn_swb: 1657250369
own_urn: urn:nbn:de:bsz:16-heidok-242745
language: eng
bibsort: RESSINGMEISTRENGTHEN2018
full_text_status: public
publication: BMC Public Health
volume: 18
number: 235
place_of_pub: London
pagerange: 2-11
issn: 1471-2458
citation:   Ressing, Meike ; Wardelmann, Eva ; Hohenberger, Peter ; Jakob, Jens ; Kasper, Bernd ; Emrich, Katharina ; Eberle, Andrea ; Blettner, Maria ; Zeissig, Sylke R.  (2018) Strengthening health data on a rare and heterogeneous disease: sarcoma incidence and histological subtypes in Germany.  BMC Public Health, 18 (235).  pp. 2-11.  ISSN 1471-2458     
document_url: https://archiv.ub.uni-heidelberg.de/volltextserver/24274/1/12889_2018_Article_5131.pdf