<> "The repository administrator has not yet configured an RDF license."^^ . <> . . . "Sox5 is involved in germ-cell regulation and sex determination in medaka following co-option of nested transposable elements"^^ . "Background: Sex determination relies on a hierarchically structured network of genes, and is one of the most plastic processes in evolution. The evolution of sex-determining genes within a network, by neo- or sub-functionalization, also requires the regulatory landscape to be rewired to accommodate these novel gene functions. We previously showed that in medaka fish, the regulatory landscape of the master male-determining gene dmrt1bY underwent a profound rearrangement, concomitantly with acquiring a dominant position within the sex-determining network. This rewiring was brought about by the exaptation of a transposable element (TE) called Izanagi, which is co-opted to act as a silencer to turn off the dmrt1bY gene after it performed its function in sex determination. \r\n\r\nResults: We now show that a second TE, Rex1, has been incorporated into Izanagi. The insertion of Rex1 brought in a preformed regulatory element for the transcription factor Sox5, which here functions in establishing the temporal and cell-type-specific expression pattern of dmrt1bY. Mutant analysis demonstrates the importance of Sox5 in the gonadal development of medaka, and possibly in mice, in a dmrt1bY-independent manner. Moreover, Sox5 medaka mutants have complete female-to-male sex reversal.\r\n\r\nConclusions: Our work reveals an unexpected complexity in TE-mediated transcriptional rewiring, with the exaptation of a second TE into a network already rewired by a TE. We also show a dual role for Sox5 during sex determination: first, as an evolutionarily conserved regulator of germ-cell number in medaka, and second, by de novo regulation of dmrt1 transcriptional activity during primary sex determination due to exaptation of the Rex1 transposable element."^^ . "2018" . . . "16" . "16" . . "Springer ; BioMed Central"^^ . . . "BMC biology"^^ . . . "17477007" . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . "Yuko"^^ . "Wakamatsu"^^ . "Yuko Wakamatsu"^^ . . "Manfred"^^ . "Schartl"^^ . "Manfred Schartl"^^ . . "Hisashi"^^ . "Hashimoto"^^ . "Hisashi Hashimoto"^^ . . "Chloé"^^ . "Bertin"^^ . "Chloé Bertin"^^ . . "Cornelia"^^ . "Schmidt"^^ . "Cornelia Schmidt"^^ . . "Yann"^^ . "Guiguen"^^ . "Yann Guiguen"^^ . . "Yusuke"^^ . "Nagao"^^ . "Yusuke Nagao"^^ . . "Amaury"^^ . "Herpin"^^ . "Amaury Herpin"^^ . . "Lazaro"^^ . "Centanin"^^ . "Lazaro Centanin"^^ . . "Dagmar"^^ . "Wilhelm"^^ . "Dagmar Wilhelm"^^ . . "Susanne"^^ . "Schories"^^ . "Susanne Schories"^^ . . "Brigitte"^^ . "Mourot"^^ . "Brigitte Mourot"^^ . . . . . . "Sox5 is involved in germ-cell regulation and sex determination in medaka following co-option of nested transposable elements (PDF)"^^ . . . "12915_2018_Article_485.pdf"^^ . . . "Sox5 is involved in germ-cell regulation and sex determination in medaka following co-option of nested transposable elements (Other)"^^ . . . . . . "lightbox.jpg"^^ . . . "Sox5 is involved in germ-cell regulation and sex determination in medaka following co-option of nested transposable elements (Other)"^^ . . . . . . "preview.jpg"^^ . . . "Sox5 is involved in germ-cell regulation and sex determination in medaka following co-option of nested transposable elements (Other)"^^ . . . . . . "medium.jpg"^^ . . . "Sox5 is involved in germ-cell regulation and sex determination in medaka following co-option of nested transposable elements (Other)"^^ . . . . . . "small.jpg"^^ . . . "Sox5 is involved in germ-cell regulation and sex determination in medaka following co-option of nested transposable elements (Other)"^^ . . . . . . "indexcodes.txt"^^ . . "HTML Summary of #24279 \n\nSox5 is involved in germ-cell regulation and sex determination in medaka following co-option of nested transposable elements\n\n" . "text/html" . . . "570 Biowissenschaften, Biologie"@de . "570 Life sciences"@en . .