eprintid: 24290
rev_number: 15
eprint_status: archive
userid: 1589
dir: disk0/00/02/42/90
datestamp: 2018-05-30 09:04:55
lastmod: 2024-03-20 02:07:38
status_changed: 2018-05-30 09:04:55
type: article
metadata_visibility: show
creators_name: Berger, Anne Katrin
creators_name: Haag, Georg Martin
creators_name: Ehmann, Martin
creators_name: Byl, Anne
creators_name: Jäger, Dirk
creators_name: Springfeld, Christoph
title: Palliative chemotherapy for pancreatic adenocarcinoma: a retrospective cohort analysis of efficacy and toxicity of the FOLFIRINOX regimen focusing on the older patient
subjects: ddc-610
divisions: i-54600
divisions: i-850300
abstract: Background: Pancreatic cancer occurs more frequently in older patients, but these are underrepresented in the phase III clinical studies that established the current treatment standards. This leads to uncertainty regarding the treatment of older patients with potentially toxic but active regimens like FOLFIRINOX.

Methods: We conducted a retrospective analysis of patients treated according to the FOLFIRINOX protocol at our institution between 2010 and 2014 with a focus on older patients.

Results: Overall survival in our cohort was 10.2 months. Only 43% of patients did not need dose adaptations, but dose reductions did not lead to an inferior survival. We did not find evidence that patients aged 65 years and older deemed fit enough for palliative treatment had more toxicities or a worse outcome than younger patients.

Conclusion: We conclude that treatment with the FOLFIRINOX protocol in patients with pancreatic cancer should not be withhold from patients solely based on their chronological age but rather be based on the patient’s performance status and comorbidities.
date: 2017
publisher: BioMed Central
id_scheme: DOI
ppn_swb: 1657579220
own_urn: urn:nbn:de:bsz:16-heidok-242902
language: eng
bibsort: BERGERANNEPALLIATIVE2017
full_text_status: public
publication: BMC Gastroenterology
volume: 17
number: 143
place_of_pub: London
pagerange: 1-7
issn: 1471-230X
citation:   Berger, Anne Katrin ; Haag, Georg Martin ; Ehmann, Martin ; Byl, Anne ; Jäger, Dirk ; Springfeld, Christoph  (2017) Palliative chemotherapy for pancreatic adenocarcinoma: a retrospective cohort analysis of efficacy and toxicity of the FOLFIRINOX regimen focusing on the older patient.  BMC Gastroenterology, 17 (143).  S. 1-7.  ISSN 1471-230X     
document_url: https://archiv.ub.uni-heidelberg.de/volltextserver/24290/1/12876_2017_Article_709.pdf