eprintid: 24307
rev_number: 11
eprint_status: archive
userid: 1589
dir: disk0/00/02/43/07
datestamp: 2018-04-25 11:16:34
lastmod: 2024-07-26 15:23:54
status_changed: 2018-04-25 11:16:34
type: article
metadata_visibility: show
creators_name: Hilger-Kolb, Jennifer
creators_name: Bosle, Catherin
creators_name: Motoc, Irina
creators_name: Hoffmann, Kristina
title: Associations between dietary factors and obesity-related biomarkers in healthy children and adolescents - a systematic review
subjects: ddc-610
divisions: i-912800
abstract: Background: The obesity prevalence in children and adolescents has increased worldwide during the past 30 years. Although diet has been identified as one risk factor for developing obesity in this age group, the role of specific dietary factors is still unclear. One way to gain insight into the role of these factors might be to detect biomarkers that reflect metabolic health and to identify the associations between dietary factors and these biomarkers. This would enable nutrition-related metabolic changes to be detected early in life, which might be a promising strategy to prevent childhood obesity. However, existing literature offers only inconclusive evidence for diet and some of these obesity-related biomarkers (e.g., blood lipids). We thus conducted a systematic literature review to further examine eligible studies that investigate associations between dietary factors and 12 obesity-related biomarkers in healthy children and adolescents aged 3-18 years.

Methods: We searched the scientific databases PubMed/Medline and Web of Science Core Collection for potentially eligible articles. Our final literature search resulted in 2727 hits. After the selection process, we included 81 articles that reported on 1111 single observations on dietary factors and any of the obesity-related biomarkers.

Results: Around 81% of the total observations showed nonsignificant results. For many biomarkers we did not find enough observations to draw clear conclusions on possible associations between a dietary factor and the respective biomarker. In cases where we identified enough observations, the results were contradictory. Since these nonsignificant and inconclusive findings may impede the development of effective strategies against childhood obesity, this article takes a closer look at possible reasons for such findings. In addition, it provides action points for future research efforts.

Conclusions: In conclusion, current evidence on associations between dietary factors and obesity-related biomarkers is inconclusive. We thus provided an overview on which specific limitations may impede current research. Such knowledge is necessary to enable future research efforts to better elucidate the role of diet in the early stages of obesity development.
date: 2017
publisher: BioMed Central
id_scheme: DOI
ppn_swb: 1655269232
own_urn: urn:nbn:de:bsz:16-heidok-243076
language: eng
bibsort: HILGERKOLBASSOCIATIO2017
full_text_status: public
publication: Nutrition journal
volume: 16
number: 85
place_of_pub: London
pagerange: 1-12
issn: 1475-2891
citation:   Hilger-Kolb, Jennifer ; Bosle, Catherin ; Motoc, Irina ; Hoffmann, Kristina  (2017) Associations between dietary factors and obesity-related biomarkers in healthy children and adolescents - a systematic review.  Nutrition journal, 16 (85).  pp. 1-12.  ISSN 1475-2891     
document_url: https://archiv.ub.uni-heidelberg.de/volltextserver/24307/1/12937_2017_Article_300.pdf