<> "The repository administrator has not yet configured an RDF license."^^ . <> . . . "CD133 expression in cancer cells predicts poor prognosis of non-mucin producing intrahepatic cholangiocarcinoma"^^ . "Background; CD133 is a marker of stem cells as well cancer stem cells. This study investigated the association between CD133 expression in cancer cells and the clinical outcome of non-mucin producing intrahepatic cholangiocarcinoma (ICC).\r\n\r\nMethods: Fifty-seven non-mucin producing ICC patients were enrolled in this study. Immunohistochemistry (IHC) and immunofluorescence staining for CD133 as well as other cancer-associated proteins, including cytokeratin 19, TGF-β1, p-Smad2 and epithelial–mesenchymal transition (EMT) markers S100A4, E-Cadherin and Vimentin were analyzed.\r\n\r\nResults: IHC staining showed that tumor cells in 52.6% of patients expressed CD133. The CD133+ patients had significantly higher metastasis rate than those without CD133+ tumor cells (36.7% vs. 10.1%, p = 0.03). The CD133+ patients had shorter overall and disease-free survival time as compared to the CD133− patients. Furthermore, 90.9% of CD133+ patients developed cancer recurrence, as compared to 64.3% of CD133− patients (p = 0.02). As compared to CD133− patients, tumor cells in CD133+ patients demonstrated high levels of TGF-β/p-Smad2 as well as EMT-like alteration, characterized by loss of E-Cadherin and expression of Vimentin and S100A4.\r\n\r\nConclusions: CD133 expression in ICC tumor cells indicates poor prognosis of the disease and might be associated with TGF-β related EMT alterations."^^ . "2018" . . . "16" . "50" . . "BioMed Central"^^ . . . "Journal of Translational Medicine"^^ . . . "14795876" . . . . . . . . . . . . . . . . . . . . . . . . . . "Xiaodong"^^ . "Yuan"^^ . "Xiaodong Yuan"^^ . . "Jun"^^ . "Li"^^ . "Jun Li"^^ . . "Xinjian"^^ . "Wan"^^ . "Xinjian Wan"^^ . . "Honglei"^^ . "Weng"^^ . "Honglei Weng"^^ . . "Lungen"^^ . "Lu"^^ . "Lungen Lu"^^ . . "Xiaobo"^^ . "Cai"^^ . "Xiaobo Cai"^^ . . "Steven"^^ . "Dooley"^^ . "Steven Dooley"^^ . . "Jingbo"^^ . "Xiao"^^ . "Jingbo Xiao"^^ . . . . . . "CD133 expression in cancer cells predicts poor prognosis of non-mucin producing intrahepatic cholangiocarcinoma (PDF)"^^ . . . "12967_2018_Article_1423.pdf"^^ . . . "CD133 expression in cancer cells predicts poor prognosis of non-mucin producing intrahepatic cholangiocarcinoma (Other)"^^ . . . . . . "lightbox.jpg"^^ . . . "CD133 expression in cancer cells predicts poor prognosis of non-mucin producing intrahepatic cholangiocarcinoma (Other)"^^ . . . . . . "preview.jpg"^^ . . . "CD133 expression in cancer cells predicts poor prognosis of non-mucin producing intrahepatic cholangiocarcinoma (Other)"^^ . . . . . . "medium.jpg"^^ . . . "CD133 expression in cancer cells predicts poor prognosis of non-mucin producing intrahepatic cholangiocarcinoma (Other)"^^ . . . . . . "small.jpg"^^ . . . "CD133 expression in cancer cells predicts poor prognosis of non-mucin producing intrahepatic cholangiocarcinoma (Other)"^^ . . . . . . "indexcodes.txt"^^ . . "HTML Summary of #24316 \n\nCD133 expression in cancer cells predicts poor prognosis of non-mucin producing intrahepatic cholangiocarcinoma\n\n" . "text/html" . . . "610 Medizin"@de . "610 Medical sciences Medicine"@en . .