title: Proteome-wide comparison between the amino acid composition of domains and linkers
creator: Brüne, Daniel
creator: Navarro, Miguel A.
creator: Mier, Pablo
subject: ddc-570
subject: 570 Life sciences
description: Objective: Amino acid composition is a sequence feature that has been extensively used to characterize proteomes of many species and protein families. Yet the analysis of amino acid composition of protein domains and the linkers connecting them has received less attention. Here, we perform both a comprehensive full-proteome amino acid composition analysis and a similar analysis focusing on domains and linkers, to uncover domain- or linker-specific differential amino acid usage patterns.    Results: The amino acid composition in the 38 proteomes studied showcase the greater variability found in archaea and bacteria species compared to eukaryotes. When focusing on domains and linkers, we describe the preferential use of polar residues in linkers and hydrophobic residues in domains. To let any user perform this analysis on a given domain (or set of them), we developed a dedicated R script called RACCOON, which can be easily used and can provide interesting insights into the compositional differences between a domain and its surrounding linkers.
publisher: BioMed Central
date: 2018
type: Article
type: info:eu-repo/semantics/article
type: NonPeerReviewed
format: application/pdf
identifier: https://archiv.ub.uni-heidelberg.de/volltextserverhttps://archiv.ub.uni-heidelberg.de/volltextserver/24333/1/13104_2018_Article_3221.pdf
identifier: DOI:
identifier: urn:nbn:de:bsz:16-heidok-243339
identifier:   Brüne, Daniel ; Navarro, Miguel A. ; Mier, Pablo  (2018) Proteome-wide comparison between the amino acid composition of domains and linkers.  BMC Research Notes, 11 (117).  pp. 1-6.  ISSN 1756-0500     
relation: https://archiv.ub.uni-heidelberg.de/volltextserver/24333/
rights: info:eu-repo/semantics/openAccess
rights: Please see front page of the work (Sorry, Dublin Core plugin does not recognise license id)
language: eng