eprintid: 24348
rev_number: 15
eprint_status: archive
userid: 1589
dir: disk0/00/02/43/48
datestamp: 2018-05-30 09:03:00
lastmod: 2024-05-06 11:50:07
status_changed: 2018-05-30 09:03:00
type: article
metadata_visibility: show
creators_name: Palm, Viktoria
creators_name: Sheng, Ruofan
creators_name: Mayer, Philipp
creators_name: Weiss, Karl-Heinz
creators_name: Springfeld, Christoph
creators_name: Mehrabi, Arianeb
creators_name: Longerich, Thomas
creators_name: Berger, Anne Katrin
creators_name: Kauczor, Hans-Ulrich
creators_name: Weber, Tim Frederik
title: Imaging features of fibrolamellar hepatocellular carcinoma in gadoxetic acid-enhanced MRI
subjects: ddc-610
divisions: i-910200
divisions: i-911400
divisions: i-912000
abstract: Background: Fibrolamellar hepatocellular carcinoma (FLC) is a rare malignancy occurring in young patients without cirrhosis. Objectives of our study were to analyze contrast material uptake in hepatobiliary phase imaging (HBP) in gadoxetic acid-enhanced liver MRI in patients with FLC and to characterize imaging features in sequence techniques other than HBP.

Methods: In this retrospective study on histology-proven FLC, contrast material uptake in HBP was quantitatively assessed by calculating the corrected FLC enhancement index (CEI) using mean signal intensities of FLC and lumbar muscle on pre-contrast imaging and HBP, respectively. Moreover, enhancement patterns in dynamic contrast-enhanced MRI and relative signal intensities compared with background liver parenchyma were determined by two radiologists in consensus for HBP, diffusion-weighted imaging using high b-values (DWI), and T2 and T1 weighted pre-contrast imaging.

Results: In 6 of 13 patients with FLC gadoxetic acid-enhanced liver MRI was available. The CEI suggested presence of HBP contrast material uptake in all FLCs. A mean CEI of 1.35 indicated FLC signal increase of 35% in HBP compared with pre-contrast imaging. All FLCs were hypointense in HBP compared with background liver parenchyma. Three of 6 FLCs had arterial hyperenhancement and venous wash-out. In DWI and T2 weighted imaging, 5 of 6 FLCs were hyperintense. In T1 weighted imaging, 5 of 6 FLCs were hypointense.

Conclusion: Hepatobiliary uptake of gadoxetic acid was quantitatively measurable in all FLCs investigated in our study. The observation of hypointensity of FLCs in HBP compared with background liver parenchyma emphasizes the role of gadoxetic acid-enhanced liver MRI for non-invasive diagnosis of FLC and its importance in the diagnostic work-up of indeterminate liver lesions.
date: 2018
publisher: BioMed Central
id_scheme: DOI
ppn_swb: 1653356987
own_urn: urn:nbn:de:bsz:16-heidok-243488
language: eng
bibsort: PALMVIKTORIMAGINGFEA2018
full_text_status: public
publication: Cancer Imaging
volume: 18
number: 9
place_of_pub: Lodon
pagerange: 1-10
issn: 1470-7330
citation:   Palm, Viktoria ; Sheng, Ruofan ; Mayer, Philipp ; Weiss, Karl-Heinz ; Springfeld, Christoph ; Mehrabi, Arianeb ; Longerich, Thomas ; Berger, Anne Katrin ; Kauczor, Hans-Ulrich ; Weber, Tim Frederik  (2018) Imaging features of fibrolamellar hepatocellular carcinoma in gadoxetic acid-enhanced MRI.  Cancer Imaging, 18 (9).  pp. 1-10.  ISSN 1470-7330     
document_url: https://archiv.ub.uni-heidelberg.de/volltextserver/24348/1/40644_2018_Article_143.pdf