title: Ioncopy: an R Shiny app to call copy number alterations in targeted NGS data
creator: Budczies, Jan
creator: Pfarr, Nicole
creator: Romanovsky, Eva
creator: Endris, Volker
creator: Stenzinger, Albrecht
creator: Denkert, Carsten
subject: ddc-610
subject: 610 Medical sciences Medicine
description: Background: Somatic copy number alterations (CNAs) contribute to the clinically targetable aberrations in the tumor genome. For both routine diagnostics and biomarkers research, CNA analysis in a single assay together with somatic mutations is highly desirable.    Results: Ioncopy is a validated method and easy-to-use software for CNA calling from targeted NGS data. Copy number and significance of CNA are estimated for each gene in each sample. Copy number gains and losses are called after multiple testing corrections controlling FWER or FDR.    Conclusions: Ioncopy facilitates calling of CNAs in a cohort of tumors tissues with or without using normal (germline) DNA controls.
publisher: BioMed Central ; Springer
date: 2018
type: Article
type: info:eu-repo/semantics/article
type: NonPeerReviewed
format: application/pdf
identifier: https://archiv.ub.uni-heidelberg.de/volltextserverhttps://archiv.ub.uni-heidelberg.de/volltextserver/24421/1/12859_2018_Article_2159.pdf
identifier: DOI:
identifier: urn:nbn:de:bsz:16-heidok-244215
identifier:   Budczies, Jan ; Pfarr, Nicole ; Romanovsky, Eva ; Endris, Volker ; Stenzinger, Albrecht ; Denkert, Carsten  (2018) Ioncopy: an R Shiny app to call copy number alterations in targeted NGS data.  BMC Bioinformatics, 19 (157).  pp. 1-4.  ISSN 1471-2105     
relation: https://archiv.ub.uni-heidelberg.de/volltextserver/24421/
rights: info:eu-repo/semantics/openAccess
rights: Please see front page of the work (Sorry, Dublin Core plugin does not recognise license id)
language: eng