title: Association between abdominal adiposity and subclinical measures of left-ventricular remodeling in diabetics, prediabetics and normal controls without history of cardiovascular disease as measured by magnetic resonance imaging: results from the KORA-FF4 Study
creator: Schlett, Christopher L.
creator: Lorbeer, Roberto
creator: Arndt, Carolyn
creator: Auweter, Sigrid
creator: Machann, Jürgen
creator: Hetterich, Holger
creator: Linkohr, Birgit
creator: Rathmann, Wolfgang
creator: Peters, Annette
creator: Bamberg, Fabian
subject: ddc-610
subject: 610 Medical sciences Medicine
description: Objectives: Local, abdominal fat depots may be related to alterations in cardiac function and morphology due to a metabolic linkage. Thus, we aimed to determine their association with subtle cardiac changes and the potential interaction with hyperglycemic metabolic states.    Methods: Subjects from the general population and without history of cardiovascular disease were drawn from the Cooperative Health Research in the Region of Augsburg FF4 cohort and underwent 3 T cardiac and body MRI. Measures of abdominal adiposity such as hepatic proton-density fat fraction [PDFFhepatic], subcutaneous (SAT) and visceral abdominal fat (VAT) as well as established cardiac left-ventricular (LV) measures including LV remodeling index (LVCI) were derived. Associations were determined using linear regression analysis based on standard deviation normalized predictors.    Results: Among a total of 374 subjects (56.2 ± 9.1 years, 58% males), 49 subjects had diabetes, 99 subjects had prediabetes and 226 represented normal controls. Only subtle cardiac alterations were observed (e.g. LVCI: 1.13 ± 0.30). While SAT was not associated, increasing VAT and increasing PDFFhepatic were independently associated with increasing LVCI (β = 0.11 and 0.06, respectively), decreasing LV end-diastolic volume (β = − 6.70 and 3.23, respectively), and decreasing LV stroke volume (β = − 3.91 and − 2.20, respectively). Hyperglycemic state did not modify the associations between VAT or PDFF and LV measures (interaction term: all p ≥ 0.29).    Conclusion: In a healthy population, VAT but also PDFFhepatic were associated with subclinical measures of LV remodeling without evidence for a modifying effect of hyperglycemic state.
publisher: BioMed Central
date: 2018
type: Article
type: info:eu-repo/semantics/article
type: NonPeerReviewed
format: application/pdf
identifier: https://archiv.ub.uni-heidelberg.de/volltextserverhttps://archiv.ub.uni-heidelberg.de/volltextserver/24728/1/12933_2018_Article_721.pdf
identifier: DOI:
identifier: urn:nbn:de:bsz:16-heidok-247289
identifier:   Schlett, Christopher L. ; Lorbeer, Roberto ; Arndt, Carolyn ; Auweter, Sigrid ; Machann, Jürgen ; Hetterich, Holger ; Linkohr, Birgit ; Rathmann, Wolfgang ; Peters, Annette ; Bamberg, Fabian  (2018) Association between abdominal adiposity and subclinical measures of left-ventricular remodeling in diabetics, prediabetics and normal controls without history of cardiovascular disease as measured by magnetic resonance imaging: results from the KORA-FF4 Study.  Cardiovascular diabetology, 17 (88).  pp. 1-12.  ISSN 1475-2840     
relation: https://archiv.ub.uni-heidelberg.de/volltextserver/24728/
rights: info:eu-repo/semantics/openAccess
rights: Please see front page of the work (Sorry, Dublin Core plugin does not recognise license id)
language: eng