<> "The repository administrator has not yet configured an RDF license."^^ . <> . . . "Association between abdominal adiposity and subclinical measures of left-ventricular remodeling in diabetics, prediabetics and normal controls without history of cardiovascular disease as measured by magnetic resonance imaging: results from the KORA-FF4 Study"^^ . "Objectives: Local, abdominal fat depots may be related to alterations in cardiac function and morphology due to a metabolic linkage. Thus, we aimed to determine their association with subtle cardiac changes and the potential interaction with hyperglycemic metabolic states.\r\n\r\nMethods: Subjects from the general population and without history of cardiovascular disease were drawn from the Cooperative Health Research in the Region of Augsburg FF4 cohort and underwent 3 T cardiac and body MRI. Measures of abdominal adiposity such as hepatic proton-density fat fraction [PDFFhepatic], subcutaneous (SAT) and visceral abdominal fat (VAT) as well as established cardiac left-ventricular (LV) measures including LV remodeling index (LVCI) were derived. Associations were determined using linear regression analysis based on standard deviation normalized predictors.\r\n\r\nResults: Among a total of 374 subjects (56.2 ± 9.1 years, 58% males), 49 subjects had diabetes, 99 subjects had prediabetes and 226 represented normal controls. Only subtle cardiac alterations were observed (e.g. LVCI: 1.13 ± 0.30). While SAT was not associated, increasing VAT and increasing PDFFhepatic were independently associated with increasing LVCI (β = 0.11 and 0.06, respectively), decreasing LV end-diastolic volume (β = − 6.70 and 3.23, respectively), and decreasing LV stroke volume (β = − 3.91 and − 2.20, respectively). Hyperglycemic state did not modify the associations between VAT or PDFF and LV measures (interaction term: all p ≥ 0.29).\r\n\r\nConclusion: In a healthy population, VAT but also PDFFhepatic were associated with subclinical measures of LV remodeling without evidence for a modifying effect of hyperglycemic state."^^ . "2018" . . "17" . "88" . . "BioMed Central"^^ . . . "Cardiovascular diabetology"^^ . . . "14752840" . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . "Wolfgang"^^ . "Rathmann"^^ . "Wolfgang Rathmann"^^ . . "Christopher L."^^ . "Schlett"^^ . "Christopher L. Schlett"^^ . . "Roberto"^^ . "Lorbeer"^^ . "Roberto Lorbeer"^^ . . "Annette"^^ . "Peters"^^ . "Annette Peters"^^ . . "Sigrid"^^ . "Auweter"^^ . "Sigrid Auweter"^^ . . "Fabian"^^ . "Bamberg"^^ . "Fabian Bamberg"^^ . . "Birgit"^^ . "Linkohr"^^ . "Birgit Linkohr"^^ . . "Holger"^^ . "Hetterich"^^ . "Holger Hetterich"^^ . . "Jürgen"^^ . "Machann"^^ . "Jürgen Machann"^^ . . "Carolyn"^^ . "Arndt"^^ . "Carolyn Arndt"^^ . . . . . . "Association between abdominal adiposity and subclinical measures of left-ventricular remodeling in diabetics, prediabetics and normal controls without history of cardiovascular disease as measured by magnetic resonance imaging: results from the KORA-FF4 Study (PDF)"^^ . . . "12933_2018_Article_721.pdf"^^ . . . "Association between abdominal adiposity and subclinical measures of left-ventricular remodeling in diabetics, prediabetics and normal controls without history of cardiovascular disease as measured by magnetic resonance imaging: results from the KORA-FF4 Study (Other)"^^ . . . . . . "lightbox.jpg"^^ . . . "Association between abdominal adiposity and subclinical measures of left-ventricular remodeling in diabetics, prediabetics and normal controls without history of cardiovascular disease as measured by magnetic resonance imaging: results from the KORA-FF4 Study (Other)"^^ . . . . . . "preview.jpg"^^ . . . "Association between abdominal adiposity and subclinical measures of left-ventricular remodeling in diabetics, prediabetics and normal controls without history of cardiovascular disease as measured by magnetic resonance imaging: results from the KORA-FF4 Study (Other)"^^ . . . . . . "medium.jpg"^^ . . . "Association between abdominal adiposity and subclinical measures of left-ventricular remodeling in diabetics, prediabetics and normal controls without history of cardiovascular disease as measured by magnetic resonance imaging: results from the KORA-FF4 Study (Other)"^^ . . . . . . "small.jpg"^^ . . . "Association between abdominal adiposity and subclinical measures of left-ventricular remodeling in diabetics, prediabetics and normal controls without history of cardiovascular disease as measured by magnetic resonance imaging: results from the KORA-FF4 Study (Other)"^^ . . . . . . "indexcodes.txt"^^ . . "HTML Summary of #24728 \n\nAssociation between abdominal adiposity and subclinical measures of left-ventricular remodeling in diabetics, prediabetics and normal controls without history of cardiovascular disease as measured by magnetic resonance imaging: results from the KORA-FF4 Study\n\n" . "text/html" . . . "610 Medizin"@de . "610 Medical sciences Medicine"@en . .