TY  - JOUR
Y1  - 2018///
TI  - Association between abdominal adiposity and subclinical measures of left-ventricular remodeling in diabetics, prediabetics and normal controls without history of cardiovascular disease as measured by magnetic resonance imaging: results from the KORA-FF4 Study
SN  - 1475-2840
A1  - Schlett, Christopher L.
A1  - Lorbeer, Roberto
A1  - Arndt, Carolyn
A1  - Auweter, Sigrid
A1  - Machann, Jürgen
A1  - Hetterich, Holger
A1  - Linkohr, Birgit
A1  - Rathmann, Wolfgang
A1  - Peters, Annette
A1  - Bamberg, Fabian
SP  - 1
UR  - https://archiv.ub.uni-heidelberg.de/volltextserver/24728/
N2  - Objectives: Local, abdominal fat depots may be related to alterations in cardiac function and morphology due to a metabolic linkage. Thus, we aimed to determine their association with subtle cardiac changes and the potential interaction with hyperglycemic metabolic states.

Methods: Subjects from the general population and without history of cardiovascular disease were drawn from the Cooperative Health Research in the Region of Augsburg FF4 cohort and underwent 3 T cardiac and body MRI. Measures of abdominal adiposity such as hepatic proton-density fat fraction [PDFFhepatic], subcutaneous (SAT) and visceral abdominal fat (VAT) as well as established cardiac left-ventricular (LV) measures including LV remodeling index (LVCI) were derived. Associations were determined using linear regression analysis based on standard deviation normalized predictors.

Results: Among a total of 374 subjects (56.2?±?9.1 years, 58% males), 49 subjects had diabetes, 99 subjects had prediabetes and 226 represented normal controls. Only subtle cardiac alterations were observed (e.g. LVCI: 1.13?±?0.30). While SAT was not associated, increasing VAT and increasing PDFFhepatic were independently associated with increasing LVCI (??=?0.11 and 0.06, respectively), decreasing LV end-diastolic volume (??=???6.70 and 3.23, respectively), and decreasing LV stroke volume (??=???3.91 and ??2.20, respectively). Hyperglycemic state did not modify the associations between VAT or PDFF and LV measures (interaction term: all p???0.29).

Conclusion: In a healthy population, VAT but also PDFFhepatic were associated with subclinical measures of LV remodeling without evidence for a modifying effect of hyperglycemic state.
JF  - Cardiovascular diabetology
CY  - London
EP  - 12
ID  - heidok24728
VL  - 17
PB  - BioMed Central
AV  - public
IS  - 88
ER  -