title: Analyzing the role of transient folds during axis elongation of the Drosophila embryo
creator: Schütz, Lucas Christopher
subject: ddc-570
subject: 570 Life sciences
description: The body plan of every higher animal is formed in a series of tissue folding and  migration events called gastrulation. At the end of gastrulation, the three tissue  layers ectoderm, mesoderm and endoderm are defined. In addition to the formation  of these tissue layers, the embryo of the fruit fly Drosophila melanogaster  extends during gastrulation along its head-to-tail axis. During this process of  germband extension, the embryo doubles the germband in size and folds it onto  itself. Germband extension coincides at the future head and tail by invagination  of the gut and is accompanied by the formation of transient folds in the head  (cephalic furrow) and back (dorsal folds) of the embryo. Some of these events,  like the formation of the posterior gut, provide support for germband extension.  Other events such as invagination and rotation of the cephalic furrow, or anterior  and posterior invagination of the dorsal folds coincide with germband extension  dynamics in a spatial and temporal manner, but their function or relationship  with respect to germband extension remains unknown. In my thesis I established  tools for the qualitative and quantitative analysis of folds and the epithelium of  the Drosophila embryo. These tools allowed me to address the putative function of  these transient folds by quantitative analyses of whole mount time lapse recordings  in the developing Drosophila embryo, giving me a new global picture of motion  dynamics in the Drosophila embryo.
date: 2018
type: Dissertation
type: info:eu-repo/semantics/doctoralThesis
type: NonPeerReviewed
format: application/pdf
identifier: https://archiv.ub.uni-heidelberg.de/volltextserverhttps://archiv.ub.uni-heidelberg.de/volltextserver/25338/1/Thesis_Schuetz.pdf
identifier: DOI:10.11588/heidok.00025338
identifier: urn:nbn:de:bsz:16-heidok-253388
identifier:   Schütz, Lucas Christopher  (2018) Analyzing the role of transient folds during axis elongation of the Drosophila embryo.  [Dissertation]     
relation: https://archiv.ub.uni-heidelberg.de/volltextserver/25338/
rights: info:eu-repo/semantics/openAccess
rights: http://archiv.ub.uni-heidelberg.de/volltextserver/help/license_urhg.html
language: eng