eprintid: 25338
rev_number: 15
eprint_status: archive
userid: 4009
dir: disk0/00/02/53/38
datestamp: 2018-10-05 16:10:47
lastmod: 2018-10-30 18:59:53
status_changed: 2018-10-05 16:10:47
type: doctoralThesis
metadata_visibility: show
creators_name: Schütz, Lucas Christopher
title: Analyzing the role of transient folds during axis elongation of the Drosophila embryo
subjects: ddc-570
divisions: i-140001
adv_faculty: af-14
abstract: The body plan of every higher animal is formed in a series of tissue folding and
migration events called gastrulation. At the end of gastrulation, the three tissue
layers ectoderm, mesoderm and endoderm are defined. In addition to the formation
of these tissue layers, the embryo of the fruit fly Drosophila melanogaster
extends during gastrulation along its head-to-tail axis. During this process of
germband extension, the embryo doubles the germband in size and folds it onto
itself. Germband extension coincides at the future head and tail by invagination
of the gut and is accompanied by the formation of transient folds in the head
(cephalic furrow) and back (dorsal folds) of the embryo. Some of these events,
like the formation of the posterior gut, provide support for germband extension.
Other events such as invagination and rotation of the cephalic furrow, or anterior
and posterior invagination of the dorsal folds coincide with germband extension
dynamics in a spatial and temporal manner, but their function or relationship
with respect to germband extension remains unknown. In my thesis I established
tools for the qualitative and quantitative analysis of folds and the epithelium of
the Drosophila embryo. These tools allowed me to address the putative function of
these transient folds by quantitative analyses of whole mount time lapse recordings
in the developing Drosophila embryo, giving me a new global picture of motion
dynamics in the Drosophila embryo.
date: 2018
id_scheme: DOI
id_number: 10.11588/heidok.00025338
ppn_swb: 1656907534
own_urn: urn:nbn:de:bsz:16-heidok-253388
date_accepted: 2018-09-14
advisor: HASH(0x55de57a16b78)
language: eng
bibsort: SCHUTZLUCAANALYZINGT2018
full_text_status: public
place_of_pub: Heidelberg
citation:   Schütz, Lucas Christopher  (2018) Analyzing the role of transient folds during axis elongation of the Drosophila embryo.  [Dissertation]     
document_url: https://archiv.ub.uni-heidelberg.de/volltextserver/25338/1/Thesis_Schuetz.pdf