<> "The repository administrator has not yet configured an RDF license."^^ . <> . . . "Tolvaptan treatment improves survival of cirrhotic patients with ascites and hyponatremia"^^ . "Background: Although tolvaptan treatment improves hyponatremia, only few studies have investigated whether tolvaptan actually benefits the survival of cirrhotic patients. This study evaluated the impact of tolvaptan on six-month survival of decompensated cirrhotic patients with and without hyponatremia. \r\n\r\nMethods: Two hundred forty-nine decompensated cirrhotic patients with or without hyponatremia were enrolled in a multicenter cohort study. Patients were divided into two groups according to receiving either tolvaptan or placebo treatment for 7-day. Subsequently, the patients were followed up for 6 months. \r\n\r\nResults: Two hundred thirty patients, including 98 with hyponatremia (tolvaptan vs. placebo: 69 vs. 29) finished the study. Tolvaptan did not alter serum sodium levels and survival outcome of decompensated cirrhotic patients without hyponatremia. However, tolvaptan treatment remarkably improved serum sodium levels and six-month survival in patients with hyponatremia. Following tolvaptan treatment, serum sodium levels were restored to normal in 63.8% of patients, whereas in patients receiving placebo, only 36.2% showed the same effect (P < 0.05). Compared to a six-month survival rate of 68.97% in patients receiving placebo, the survival rate in tolvapatan-treated patients was 89.94% (P < 0.05). Furthermore, six-month survival rate in the tolvaptan-treated hyponatremia patients with resolved serum sodium was 81.32%, whereas the survival in those with unresolved serum sodium was only 24% (P < 0.05).\r\n\r\nConclusions: Tolvaptan improves short term survival in most decompensated cirrhotic hyponatremia patients with resolved serum sodium.\r\n\r\nTrials registration: Clinical trial one: ClinicalTrials.gov ID: NCT00664014 , Registered on April 14, 2008. Clinical trial two: ClinicalTrials.gov ID: NCT01349335 , Registered on March 5, 2010. Clinical trial three: ClinicalTrials.gov ID: NCT01349348 , Registered on May 4, 2011."^^ . "2018" . . "18" . "137" . . "BioMed Central"^^ . . . "BMC Gastroenterology"^^ . . . "1471230X" . . . . . . . . . . . . . . . . . . . . . . . . . . . . . "Yonggang"^^ . "Li"^^ . "Yonggang Li"^^ . . "Tao"^^ . "Han"^^ . "Tao Han"^^ . . "Honglei"^^ . "Weng"^^ . "Honglei Weng"^^ . . "Hong"^^ . "Ma"^^ . "Hong Ma"^^ . . "Xin"^^ . "Zhang"^^ . "Xin Zhang"^^ . . "Wen"^^ . "Xie"^^ . "Wen Xie"^^ . . "Shuzhen"^^ . "Wang"^^ . "Shuzhen Wang"^^ . . "Roman"^^ . "Liebe"^^ . "Roman Liebe"^^ . . "Hui-Guo"^^ . "Ding"^^ . "Hui-Guo Ding"^^ . . . . . . "Tolvaptan treatment improves survival of cirrhotic patients with ascites and hyponatremia (PDF)"^^ . . . "12876_2018_Article_857.pdf"^^ . . . "Tolvaptan treatment improves survival of cirrhotic patients with ascites and hyponatremia (Other)"^^ . . . . . . "lightbox.jpg"^^ . . . "Tolvaptan treatment improves survival of cirrhotic patients with ascites and hyponatremia (Other)"^^ . . . . . . "preview.jpg"^^ . . . "Tolvaptan treatment improves survival of cirrhotic patients with ascites and hyponatremia (Other)"^^ . . . . . . "medium.jpg"^^ . . . "Tolvaptan treatment improves survival of cirrhotic patients with ascites and hyponatremia (Other)"^^ . . . . . . "small.jpg"^^ . . . "Tolvaptan treatment improves survival of cirrhotic patients with ascites and hyponatremia (Other)"^^ . . . . . . "indexcodes.txt"^^ . . "HTML Summary of #25459 \n\nTolvaptan treatment improves survival of cirrhotic patients with ascites and hyponatremia\n\n" . "text/html" . . . "610 Medizin"@de . "610 Medical sciences Medicine"@en . .