title: Type 2 diabetes is independently associated with all-cause mortality secondary to ventricular tachyarrhythmias
creator: Weidner, Kathrin
creator: Behnes, Michael
creator: Schupp, Tobias
creator: Rusnak, Jonas
creator: Reiser, Linda
creator: Bollow, Armin
creator: Taton, Gabriel
creator: Reichelt, Thomas
creator: Ellguth, Dominik
creator: Engelke, Niko
creator: Hoppner, Jorge
creator: El-Battrawy, Ibrahim
creator: Mashayekhi, Kambis
creator: Weiß, Christel
creator: Borggrefe, Martin
creator: Akin, Ibrahim
subject: 610
subject: 610 Medical sciences Medicine
description: Objectives: The study sought to assess the prognostic impact of type 2 diabetes in patients presenting with ventricular tachyarrhythmias on admission.    Background: Data regarding the prognostic outcome of diabetics presenting with ventricular tachyarrhythmias is limited.    Methods: A large retrospective registry was used including all consecutive patients presenting with ventricular tachycardia (VT) and fibrillation (VF) on admission from 2002 to 2016. Patients with type 2 diabetes (diabetics) were compared to non-diabetics applying multivariable Cox regression models and propensity-score matching for evaluation of the primary prognostic endpoint of long-term all-cause mortality at 2 years. Secondary prognostic endpoints were cardiac death at 24 h, in-hospital death at index, all-cause mortality at 30 days, all-cause mortality in patients surviving index hospitalization at 2 years (i.e. “after discharge”) and rehospitalization due to recurrent ventricular tachyarrhythmias at 2 years.    Results: In 2411 unmatched high-risk patients with ventricular tachyarrhythmias, diabetes was present in 25% compared to non-diabetics (75%). Rates of VT (57% vs. 56%) and VF (43% vs. 44%) were comparable in both groups. Multivariable Cox regression models revealed diabetics associated with the primary endpoint of long-term all-cause mortality at 2 years (HR = 1.513; p = 0.001), which was still proven after propensity score matching (46% vs. 33%, log rank p = 0.001; HR = 1.525; p = 0.001). The rates of secondary endpoints were higher for in-hospital death at index, all-cause mortality at 30 days, as well as after discharge, but not for cardiac death at 24 h or rehospitalization due to recurrent ventricular tachyarrhythmias.    Conclusion: Presence of type 2 diabetes is independently associated with an increase of all-cause mortality in patients presenting with ventricular tachyarrhythmias on admission.
publisher: BioMed Central
date: 2018
type: Article
type: info:eu-repo/semantics/article
type: NonPeerReviewed
format: application/pdf
identifier: https://archiv.ub.uni-heidelberg.de/volltextserverhttps://archiv.ub.uni-heidelberg.de/volltextserver/25462/1/12933_2018_Article_768.pdf
identifier: DOI:
identifier: urn:nbn:de:bsz:16-heidok-254627
identifier:   Weidner, Kathrin ; Behnes, Michael ; Schupp, Tobias ; Rusnak, Jonas ; Reiser, Linda ; Bollow, Armin ; Taton, Gabriel ; Reichelt, Thomas ; Ellguth, Dominik ; Engelke, Niko ; Hoppner, Jorge ; El-Battrawy, Ibrahim ; Mashayekhi, Kambis ; Weiß, Christel ; Borggrefe, Martin ; Akin, Ibrahim  (2018) Type 2 diabetes is independently associated with all-cause mortality secondary to ventricular tachyarrhythmias.  Cardiovascular diabetology, 17 (125).  pp. 1-12.  ISSN 1475-2840     
relation: https://archiv.ub.uni-heidelberg.de/volltextserver/25462/
rights: info:eu-repo/semantics/openAccess
rights: Please see front page of the work (Sorry, Dublin Core plugin does not recognise license id)
language: eng