TY  - JOUR
SN  - 1475-2840
SP  - 1
A1  - Weidner, Kathrin
A1  - Behnes, Michael
A1  - Schupp, Tobias
A1  - Rusnak, Jonas
A1  - Reiser, Linda
A1  - Bollow, Armin
A1  - Taton, Gabriel
A1  - Reichelt, Thomas
A1  - Ellguth, Dominik
A1  - Engelke, Niko
A1  - Hoppner, Jorge
A1  - El-Battrawy, Ibrahim
A1  - Mashayekhi, Kambis
A1  - Weiß, Christel
A1  - Borggrefe, Martin
A1  - Akin, Ibrahim
PB  - BioMed Central
UR  - https://archiv.ub.uni-heidelberg.de/volltextserver/25462/
Y1  - 2018///
N2  - Objectives: The study sought to assess the prognostic impact of type 2 diabetes in patients presenting with ventricular tachyarrhythmias on admission.

Background: Data regarding the prognostic outcome of diabetics presenting with ventricular tachyarrhythmias is limited.

Methods: A large retrospective registry was used including all consecutive patients presenting with ventricular tachycardia (VT) and fibrillation (VF) on admission from 2002 to 2016. Patients with type 2 diabetes (diabetics) were compared to non-diabetics applying multivariable Cox regression models and propensity-score matching for evaluation of the primary prognostic endpoint of long-term all-cause mortality at 2 years. Secondary prognostic endpoints were cardiac death at 24 h, in-hospital death at index, all-cause mortality at 30 days, all-cause mortality in patients surviving index hospitalization at 2 years (i.e. ?after discharge?) and rehospitalization due to recurrent ventricular tachyarrhythmias at 2 years.

Results: In 2411 unmatched high-risk patients with ventricular tachyarrhythmias, diabetes was present in 25% compared to non-diabetics (75%). Rates of VT (57% vs. 56%) and VF (43% vs. 44%) were comparable in both groups. Multivariable Cox regression models revealed diabetics associated with the primary endpoint of long-term all-cause mortality at 2 years (HR?=?1.513; p?=?0.001), which was still proven after propensity score matching (46% vs. 33%, log rank p?=?0.001; HR?=?1.525; p?=?0.001). The rates of secondary endpoints were higher for in-hospital death at index, all-cause mortality at 30 days, as well as after discharge, but not for cardiac death at 24 h or rehospitalization due to recurrent ventricular tachyarrhythmias.

Conclusion: Presence of type 2 diabetes is independently associated with an increase of all-cause mortality in patients presenting with ventricular tachyarrhythmias on admission.
VL  - 17
JF  - Cardiovascular diabetology
IS  - 125
TI  - Type 2 diabetes is independently associated with all-cause mortality secondary to ventricular tachyarrhythmias
CY  - London
EP  - 12
ID  - heidok25462
AV  - public
ER  -