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primary topic: Cytokines in relation to hCG are significantly altered in asymptomatic women with miscarriage – a pilot study

Cytokines in relation to hCG are significantly altered in asymptomatic women with miscarriage – a pilot study
type: AcademicArticle
type: Article
abstract: Background: Spontaneous abortion is one of the most common complications in early pregnancy. A preventive test to identify women who will experience a miscarriage, even before first symptoms occur, is not established. Activation of maternal immunological tolerance seems to be essential for early fetal development and various cytokines have been described in different stages of pregnancy. Therefore, we aimed to investigate if chemokine levels at the time of pregnancy testing relative to human Choriogonadotropin (hCG) are altered in patients who will experience a miscarriage in this pregnancy. Methods: We obtained blood samples from 39 women. Dependent on the follow-up, patients with a positive pregnancy test were subsequently divided in two groups: ongoing pregnancy (n = 22) and miscarriage (n = 17) in this pregnancy. Immunological and endocrine profiling of maternal plasma at the time of pregnancy testing (5th week of gestation) was performed for each group at the time of pregnancy test using Multiplex and ELISA analysis. Results: hCG was significantly decreased in patients with abortion whereas levels of IL-1ra, MIP-1a and TNF-alpha were significantly increased. GCSF/ IL-1ra-ratio was 1.66-fold increased in patients with ongoing pregnancy. TGF-beta /MIP1a-ratio was significantly 3.45-times higher in patients with miscarriage. Comparing patients with ongoing pregnancy to patients experiencing a miscarriage, we could demonstrate significant alterations of the ratios MIP1a/hCG, IL-1ra/hCG, TNFalpha/hCG, MCP1/hCG, IL-6/hCG, TPO/hCG and TGF-beta1/hCG. The strongest effects were seen for the ratio MIP1a/hCG, IL-1ra/hCG and TNFalpha/hCG. Conclusions: We have shown that cytokines in relation to hCG after 4 weeks of gestation are significantly altered in women with miscarriage, promising potential as a prognostic biomarker.
date: 2018
volume: 16
issue: 93
is part of: Reproductive Biology and Endocrinology
author list: authors
type: EPrint
type: ArticleEPrint
is part of: repository
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subject: 610 Medizin

Cytokines in relation to hCG are significantly altered in asymptomatic women with miscarriage – a pilot study (PDF)
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has file: 12958_2018_Article_411.pdf
has part: 12958_2018_Article_411.pdf

BioMed Central
type: Organization

Reproductive Biology and Endocrinology
type: Collection
issn: 14777827

Volker Daniel
type: Person
given name: Volker
family name: Daniel

Alexander Freis
type: Person
given name: Alexander
family name: Freis

Janina Schlegel
type: Person
given name: Janina
family name: Schlegel

Julia Jauckus
type: Person
given name: Julia
family name: Jauckus

Thomas Strowitzki
type: Person
given name: Thomas
family name: Strowitzki

Ariane Germeyer
type: Person
given name: Ariane
family name: Germeyer

Cytokines in relation to hCG are significantly altered in asymptomatic women with miscarriage – a pilot study (Other)
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Cytokines in relation to hCG are significantly altered in asymptomatic women with miscarriage – a pilot study (Other)
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Cytokines in relation to hCG are significantly altered in asymptomatic women with miscarriage – a pilot study (Other)
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primary topic: Cytokines in relation to hCG are significantly altered in asymptomatic women with miscarriage – a pilot study

610 Medizin
type: Concept
preferred label: 610 Medical sciences Medicine @en