title: Right heart size and function significantly correlate in patients with pulmonary arterial hypertension – a cross-sectional study
creator: Fischer, Lukas
creator: Benjamin, Nicola
creator: Blank, Norbert
creator: Egenlauf, Benjamin
creator: Fischer, Christine
creator: Harutyunova, Satenik
creator: Koegler, Maria
creator: Lorenz, Hanns-Martin
creator: Marra, Alberto M.
creator: Nagel, Christian
creator: Xanthouli, Panagiota
creator: Bossone, Eduardo
creator: Grünig, Ekkehard
subject: 610
subject: 610 Medical sciences Medicine
description: Background: The objective of this study was to assess, whether right atrial (RA) and ventricular (RV) size is related to RV pump function at rest and during exercise in patients with pulmonary arterial hypertension (PAH).    Methods: We included 54 patients with invasively diagnosed PAH that had been stable on targeted medication. All patients underwent clinical assessments including right heart catheterization and echocardiography at rest and during exercise. RV output reserve was defined as increase of cardiac index (CI) from rest to peak exercise (∆CIexercise). Patients were classified according to the median of RA and RV-area. RV pump function and further clinical parameters were compared between groups by student’s t-test. Uni- and multivariate Pearson correlation analyses were performed.    Results: Patients with larger RA and/or RV-areas (above a median of 16 and 20cm2, respectively) showed significantly lower ∆CIexercise, higher mean pulmonary arterial pressure, pulmonary vascular resistance at rest and NT-proBNP levels. Furthermore, patients with higher RV-areas presented with a significantly lower RV stroke volume and pulmonary arterial compliance at peak exercise than patients with smaller RV-size. RV area was identified as the only independent predictor of RV output reserve.    Conclusion: RV and RA areas represent valuable and easily accessible indicators of RV pump function at rest and during exercise. Cardiac output reserve should be considered as an important clinical parameter. Prospective studies are needed for further evaluation.
publisher: BioMed Central
date: 2018
type: Article
type: info:eu-repo/semantics/article
type: NonPeerReviewed
format: application/pdf
identifier: https://archiv.ub.uni-heidelberg.de/volltextserverhttps://archiv.ub.uni-heidelberg.de/volltextserver/25595/1/12931_2018_Article_913.pdf
identifier: DOI:https://doi.org/10.1186/s12931-018-0913-x
identifier: urn:nbn:de:bsz:16-heidok-255952
identifier:   Fischer, Lukas ; Benjamin, Nicola ; Blank, Norbert ; Egenlauf, Benjamin ; Fischer, Christine ; Harutyunova, Satenik ; Koegler, Maria ; Lorenz, Hanns-Martin ; Marra, Alberto M. ; Nagel, Christian ; Xanthouli, Panagiota ; Bossone, Eduardo ; Grünig, Ekkehard  (2018) Right heart size and function significantly correlate in patients with pulmonary arterial hypertension – a cross-sectional study.  Respiratory Research, 19 (216).  pp. 1-13.  ISSN 1465-993X     
relation: https://archiv.ub.uni-heidelberg.de/volltextserver/25595/
rights: info:eu-repo/semantics/openAccess
rights: Please see front page of the work (Sorry, Dublin Core plugin does not recognise license id)
language: eng