eprintid: 25595
rev_number: 16
eprint_status: archive
userid: 1589
dir: disk0/00/02/55/95
datestamp: 2019-01-03 16:12:47
lastmod: 2019-01-09 10:18:50
status_changed: 2019-01-03 16:12:47
type: article
metadata_visibility: show
creators_name: Fischer, Lukas
creators_name: Benjamin, Nicola
creators_name: Blank, Norbert
creators_name: Egenlauf, Benjamin
creators_name: Fischer, Christine
creators_name: Harutyunova, Satenik
creators_name: Koegler, Maria
creators_name: Lorenz, Hanns-Martin
creators_name: Marra, Alberto M.
creators_name: Nagel, Christian
creators_name: Xanthouli, Panagiota
creators_name: Bossone, Eduardo
creators_name: Grünig, Ekkehard
title: Right heart size and function significantly correlate in patients with pulmonary arterial hypertension – a cross-sectional study
subjects: 610
divisions: 910100
divisions: 911500
divisions: 942000
keywords: Pulmonary hypertension, Right ventricular output reserve, Pump function, Right ventricular size, Right atrial size
abstract: Background: The objective of this study was to assess, whether right atrial (RA) and ventricular (RV) size is related to RV pump function at rest and during exercise in patients with pulmonary arterial hypertension (PAH).

Methods: We included 54 patients with invasively diagnosed PAH that had been stable on targeted medication. All patients underwent clinical assessments including right heart catheterization and echocardiography at rest and during exercise. RV output reserve was defined as increase of cardiac index (CI) from rest to peak exercise (∆CIexercise). Patients were classified according to the median of RA and RV-area. RV pump function and further clinical parameters were compared between groups by student’s t-test. Uni- and multivariate Pearson correlation analyses were performed.

Results: Patients with larger RA and/or RV-areas (above a median of 16 and 20cm2, respectively) showed significantly lower ∆CIexercise, higher mean pulmonary arterial pressure, pulmonary vascular resistance at rest and NT-proBNP levels. Furthermore, patients with higher RV-areas presented with a significantly lower RV stroke volume and pulmonary arterial compliance at peak exercise than patients with smaller RV-size. RV area was identified as the only independent predictor of RV output reserve.

Conclusion: RV and RA areas represent valuable and easily accessible indicators of RV pump function at rest and during exercise. Cardiac output reserve should be considered as an important clinical parameter. Prospective studies are needed for further evaluation.
date: 2018
publisher: BioMed Central
id_scheme: DOI
id_number: https://doi.org/10.1186/s12931-018-0913-x
ppn_swb: 1653309202
own_urn: urn:nbn:de:bsz:16-heidok-255952
language: eng
bibsort: FISCHERLUKRIGHTHEART2018
full_text_status: public
publication: Respiratory Research
volume: 19
number: 216
place_of_pub: London
pagerange: 1-13
issn: 1465-993X
citation:   Fischer, Lukas ; Benjamin, Nicola ; Blank, Norbert ; Egenlauf, Benjamin ; Fischer, Christine ; Harutyunova, Satenik ; Koegler, Maria ; Lorenz, Hanns-Martin ; Marra, Alberto M. ; Nagel, Christian ; Xanthouli, Panagiota ; Bossone, Eduardo ; Grünig, Ekkehard  (2018) Right heart size and function significantly correlate in patients with pulmonary arterial hypertension – a cross-sectional study.  Respiratory Research, 19 (216).  pp. 1-13.  ISSN 1465-993X     
document_url: https://archiv.ub.uni-heidelberg.de/volltextserver/25595/1/12931_2018_Article_913.pdf