eprintid: 25658
rev_number: 13
eprint_status: archive
userid: 1589
dir: disk0/00/02/56/58
datestamp: 2019-01-30 14:42:58
lastmod: 2019-02-13 14:05:27
status_changed: 2019-01-30 14:42:58
type: article
metadata_visibility: show
creators_name: Morche, Johannes
creators_name: Mathes, Tim
creators_name: Jacobs, Anja
creators_name: Pietsch, Barbara
creators_name: Wessel, Lucas
creators_name: Gruber, Sabine
creators_name: Neugebauer, Edmund A. M.
creators_name: Pieper, Dawid
title: Relationship between volume and outcome for congenital diaphragmatic hernia: a systematic review protocol
subjects: 610
divisions: 63700
keywords: Congenital diaphragmatic hernia, Congenital abnormalities, Hospitals, High-Volume, Hospitals, Low-Volume, Hospital volume, Surgeon volume, Volume–outcome
abstract: Background: Congenital diaphragmatic hernia is a rare and life-threatening anomaly that occurs during fetal development and results in an incomplete or incorrect formation of the diaphragm. Surgical therapy of the diaphragm should be performed after clinical stabilization of the neonate. Higher hospital or surgeon volume has previously been found to be associated with better clinical outcomes for different especially high-risk, low-volume procedures. Therefore, we aim to examine the relationship between hospital or surgeon volume and outcomes for congenital diaphragmatic hernia.

Methods: This systematic review protocol has been designed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analysis Protocol. We will perform a systematic literature search in MEDLINE, Embase, CINAHL and Biosis Previews without applying any limitations. In addition, we will search for relevant conference abstracts. We will screen titles and abstracts of retrieved studies, obtain potentially relevant full texts, and assess the eligibility of those full texts against our inclusion criteria. We will include comparative studies analyzing the relationship between hospital or surgeon volume and clinical outcomes. We will systematically assess risk of bias of included studies and extract data on the study design, patient characteristics, case-mix adjustments, statistical methods, hospital and surgeon volume, and outcomes into standardized tables. Title and abstract screening, full-text screening, critical appraisal, and data extraction of results will be conducted by two reviewers independently. Other data will be extracted by one reviewer and checked for accuracy by a second one. Any disagreements will be resolved by discussion. We will not perform a meta-analysis as we expect included studies to be clinically and methodologically very diverse. We will synthesize findings from primary studies in a structured narrative way and using GRADE.

Discussion: Given the lack of a comprehensive summary of findings on the relationship between hospital or surgeon volume and outcomes for congenital diaphragmatic hernia, this systematic review will put things right. Results can be used to inform decision makers or clinicians and to adapt medical care.

Systematic review registration: PROSPERO (CRD42018090231)
date: 2018
publisher: BioMed Central
id_scheme: DOI
id_number: https://doi.org/10.1186/s13643-018-0872-9
ppn_swb: 165508285X
own_urn: urn:nbn:de:bsz:16-heidok-256586
language: eng
bibsort: MORCHEJOHARELATIONSH2018
full_text_status: public
publication: Systematic Reviews
volume: 7
number: 185
place_of_pub: London
pagerange: 1-5
issn: 2046-4053
citation:   Morche, Johannes ; Mathes, Tim ; Jacobs, Anja ; Pietsch, Barbara ; Wessel, Lucas ; Gruber, Sabine ; Neugebauer, Edmund A. M. ; Pieper, Dawid  (2018) Relationship between volume and outcome for congenital diaphragmatic hernia: a systematic review protocol.  Systematic Reviews, 7 (185).  pp. 1-5.  ISSN 2046-4053     
document_url: https://archiv.ub.uni-heidelberg.de/volltextserver/25658/1/13643_2018_Article_872.pdf