<> "The repository administrator has not yet configured an RDF license."^^ . <> . . "Analysis of annexin-mediated antigen-specific\r\nimmunosuppression"^^ . "Apoptotic cells mediate the development of tolerogenic dendritic cells (DC) and thus facilitate\r\nthe induction and maintenance of peripheral tolerance. Our group investigated the\r\ninfluence of apoptotic cells on DC and identified the cell surface exposure of the evolutionary\r\nconserved annexin core domain (Anx) as a specific signal which antagonises Toll-like\r\nreceptor (TLR) signalling.\r\nThis study examined whether the tolerogenic capacity of Anx can be exploited to downregulate\r\nantigen-specific immune responses to the model antigen ovalbumin (Ova). The\r\ntreatment of bone marrow-derived dendritic cells (BMDC) with soluble Anx prior to Ova\r\nadministration or the treatment with beads harbouring Anx as well as Ova attenuated the\r\nresponse of Ova-specific OT-II Tcells. The co-culture of treated DC and Tcells resulted\r\nin an anergy-like phenotype characterised by reduced proliferation and cytokine secretion.\r\nThe anti-inflammatory effects of Anx are mediated through DC by yet unknown mechanisms.\r\nAnx did not lead to the tolerogenic DC phenotype described to be induced\r\nby apoptotic cells and also the previously reported suppression of anti-inflammatory cytokines\r\nby Anx was dispensable for the effect on Tcells. However, this study revealed\r\nenhanced production od reactive oxygen species (ROS) in BMDC in response to Anx\r\nwhich might affect the DC/Tcell interactions.\r\nAlthough the underlying mechanisms remain to be elucidated, this study demonstrates\r\nthat Anx can be used as a tool to generate a particle-based antigen delivery system that\r\npromotes antigen-specific immunosuppression. Such Anx-particles may be a new therapeutic\r\napproach for the treatment of autoimmune disease."^^ . "2020" . . . . . . . "Corinna"^^ . "Link"^^ . "Corinna Link"^^ . . . . . . "Analysis of annexin-mediated antigen-specific\r\nimmunosuppression (PDF)"^^ . . . "Thesis_CL_pdfa.pdf"^^ . . . "Analysis of annexin-mediated antigen-specific\r\nimmunosuppression (Other)"^^ . . . . . . "indexcodes.txt"^^ . . "HTML Summary of #25666 \n\nAnalysis of annexin-mediated antigen-specific \nimmunosuppression\n\n" . "text/html" . . . "570 Biowissenschaften, Biologie"@de . "570 Life sciences"@en . .