title: The developmental sex-biased expression of genes escaping X chromosome inactivation across mammals
creator: Studer, Tania
subject: ddc-000
subject: 000 Generalities, Science
subject: ddc-500
subject: 500 Natural sciences and mathematics
subject: ddc-570
subject: 570 Life sciences
subject: ddc-590
subject: 590 Zoological sciences
description: In mammals, X-chromosome inactivation (XCI) re-establishes the dosage balance between male and female gene expression levels. However, up to a third of the X-linked genes escape this phenomenon with varying degrees of consistency across tissues, cell lines, or individuals. Here, I take advantage of a new extensive developmental dataset for several organs and species to explore the developmental dimension of sex chromosomes expression levels. I find that only a small fraction of genes escaping XCI show a consistent female overexpression across development, organs, and species. The consistently sex-biased genes are almost exclusively either directly involved in the establishment of XCI, or are protein-coding genes with a broadly expressed Y homolog. The conservation of the sex-bias of these genes across species suggests that they might be responsible for the evolution of escape from XCI. I also present and test a model of allelic contribution to the total expression levels of X-linked genes using marsupial bulk tissue RNA sequencing data. Finally, I describe my contribution to a study of sex-biased micro-RNAs in mammals.
date: 2018
type: Dissertation
type: info:eu-repo/semantics/doctoralThesis
type: NonPeerReviewed
format: application/pdf
identifier: https://archiv.ub.uni-heidelberg.de/volltextserverhttps://archiv.ub.uni-heidelberg.de/volltextserver/25740/1/Thesis_Tania_2ref.pdf
identifier: DOI:10.11588/heidok.00025740
identifier: urn:nbn:de:bsz:16-heidok-257405
identifier:   Studer, Tania  (2018) The developmental sex-biased expression of genes escaping X chromosome inactivation across mammals.  [Dissertation]     
relation: https://archiv.ub.uni-heidelberg.de/volltextserver/25740/
rights: info:eu-repo/semantics/openAccess
rights: http://archiv.ub.uni-heidelberg.de/volltextserver/help/license_urhg.html
language: eng