title: Towards a quantum cascade laser-based implant for the continuous monitoring of glucose
creator: Isensee, Katharina
subject: 530
subject: 530 Physics
description: The continuous surveillance of the body’s glucose concentration is pivotal for the prevention of short- and long-term health complications for people with diabetes. In this thesis, mid-infrared absorption spectroscopy is investigated as an alternative  to conventional enzyme-based glucose monitors. To this end, a quantum cascade laser-based sensor system is designed and implemented with the goal to serve as an optical port for continuous, real-time spectroscopy in vivo. This transflection sensor shows high sensitivity in vitro with a glucose error of prediction as low as 4mg/dL in pure glucose solutions, 10mg=dL in the presence of proteins  and 21mg=dL in the presence of other carbohydrates. The impact of the temperature on the optical signal is investigated both theoretically and experimentally. Even under temperature variations up to 15C a glucose prediction error as low as 18:5mg/dL can be achieved. Adding a porous membrane hinders the diffusion of large molecules into the sensor while enabling glucose diffusion on the targeted time scale (<5 minutes). Finally, a stable glucose permeation and concentration prediction over more than 1 month demonstrates the potential of a quantum cascade laser-based transflection technology for application in a long-term implant for continuous glucose sensing.
date: 2018
type: Dissertation
type: info:eu-repo/semantics/doctoralThesis
type: NonPeerReviewed
format: application/pdf
identifier: https://archiv.ub.uni-heidelberg.de/volltextserverhttps://archiv.ub.uni-heidelberg.de/volltextserver/25742/1/Isensee_Diss_Final.pdf
identifier: DOI:10.11588/heidok.00025742
identifier: urn:nbn:de:bsz:16-heidok-257423
identifier:   Isensee, Katharina  (2018) Towards a quantum cascade laser-based implant for the continuous monitoring of glucose.  [Dissertation]     
relation: https://archiv.ub.uni-heidelberg.de/volltextserver/25742/
rights: info:eu-repo/semantics/openAccess
rights: http://archiv.ub.uni-heidelberg.de/volltextserver/help/license_urhg.html
language: eng