eprintid: 25742
rev_number: 16
eprint_status: archive
userid: 4170
dir: disk0/00/02/57/42
datestamp: 2018-12-19 12:19:30
lastmod: 2019-01-24 13:28:39
status_changed: 2018-12-19 12:19:30
type: doctoralThesis
metadata_visibility: show
creators_name: Isensee, Katharina
title: Towards a quantum cascade laser-based implant for the continuous monitoring of glucose
subjects: 530
divisions: 130001
adv_faculty: af-13
abstract: The continuous surveillance of the body’s glucose concentration is pivotal for the prevention of short- and long-term health complications for people with diabetes. In this thesis, mid-infrared absorption spectroscopy is investigated as an alternative
to conventional enzyme-based glucose monitors. To this end, a quantum cascade laser-based sensor system is designed and implemented with the goal to serve as an optical port for continuous, real-time spectroscopy in vivo. This transflection sensor shows high sensitivity in vitro with a glucose error of prediction as low as 4mg/dL in pure glucose solutions, 10mg=dL in the presence of proteins
and 21mg=dL in the presence of other carbohydrates. The impact of the temperature on the optical signal is investigated both theoretically and experimentally. Even under temperature variations up to 15C a glucose prediction error as low as 18:5mg/dL can be achieved. Adding a porous membrane hinders the diffusion of large molecules into the sensor while enabling glucose diffusion on the targeted time scale (<5 minutes). Finally, a stable glucose permeation and concentration prediction over more than 1 month demonstrates the potential of a quantum cascade laser-based transflection technology for application in a long-term implant for continuous glucose sensing.
date: 2018
id_scheme: DOI
id_number: 10.11588/heidok.00025742
ppn_swb: 1653731877
own_urn: urn:nbn:de:bsz:16-heidok-257423
date_accepted: 2018-12-12
advisor: HASH(0x556120927fa8)
language: eng
bibsort: ISENSEEKATTOWARDSAQU2018
full_text_status: public
place_of_pub: Heidelberg
citation:   Isensee, Katharina  (2018) Towards a quantum cascade laser-based implant for the continuous monitoring of glucose.  [Dissertation]     
document_url: https://archiv.ub.uni-heidelberg.de/volltextserver/25742/1/Isensee_Diss_Final.pdf