title: Anaemia requiring red blood cell transfusion is associated with unfavourable 90-day survival in surgical patients with sepsis
creator: Kristof, Katalin
creator: Büttner, Benedikt
creator: Grimm, Anna
creator: Mewes, Caspar
creator: Schmack, Bastian
creator: Popov, Aron Frederik
creator: Ghadimi, Michael
creator: Beissbarth, Tim
creator: Hinz, José
creator: Bergmann, Ingo
creator: Mansur, Ashham
subject: ddc-610
subject: 610 Medical sciences Medicine
description: Objective: The mortality associated with sepsis remains unacceptably high, despite modern high-quality intensive care. Based on the results from previous studies, anaemia and its management in patients with sepsis appear to impact outcomes; however, the transfusion policy is still being debated, and the ideal approach may be extremely specific to the individual. This study aimed to investigate the long-term impact of anaemia requiring red blood cell (RBC) transfusion on mortality and disease severity in patients with sepsis. We studied a general surgical intensive care unit (ICU) population, excluding cardiac surgery patients. 435 patients were enrolled in this observational study between 2012 and 2016.    Results: Patients who received RBC transfusion between 28 days before and 28 days after the development of sepsis (n = 302) exhibited a significantly higher 90-day mortality rate (34.1% vs 19.6%; P = 0.004, Kaplan–Meier analysis). This association remained significant after adjusting for confounders in the multivariate Cox regression analysis (hazard ratio 1.68; 95% confidence interval 1.03–2.73; P = 0.035). Patients who received transfusions also showed significantly higher morbidity scores, such as SOFA scores, and ICU lengths of stay compared to patients without transfusions (n = 133). Our results indicate that anaemia and RBC transfusion are associated with unfavourable outcomes in patients with sepsis.
publisher: BioMed Central
date: 2018
type: Article
type: info:eu-repo/semantics/article
type: NonPeerReviewed
format: application/pdf
identifier: https://archiv.ub.uni-heidelberg.de/volltextserverhttps://archiv.ub.uni-heidelberg.de/volltextserver/25746/1/13104_2018_Article_3988.pdf
identifier: DOI:
identifier: urn:nbn:de:bsz:16-heidok-257464
identifier:   Kristof, Katalin ; Büttner, Benedikt ; Grimm, Anna ; Mewes, Caspar ; Schmack, Bastian ; Popov, Aron Frederik ; Ghadimi, Michael ; Beissbarth, Tim ; Hinz, José ; Bergmann, Ingo ; Mansur, Ashham  (2018) Anaemia requiring red blood cell transfusion is associated with unfavourable 90-day survival in surgical patients with sepsis.  BMC Research Notes, 11 (879).  pp. 1-7.  ISSN 1756-0500     
relation: https://archiv.ub.uni-heidelberg.de/volltextserver/25746/
rights: info:eu-repo/semantics/openAccess
rights: Please see front page of the work (Sorry, Dublin Core plugin does not recognise license id)
language: eng