TY  - JOUR
ID  - heidok25746
SP  - 1
VL  - 11
IS  - 879
KW  - Sepsis
KW  -  Red blood cell transfusion
KW  -  Surgical ICU
KW  -  Mortality
KW  -  Organ dysfunction
KW  -  Survival
KW  -  Organ support
KW  -  Morbidity
Y1  - 2018///
EP  - 7
SN  - 1756-0500
A1  - Kristof, Katalin
A1  - Büttner, Benedikt
A1  - Grimm, Anna
A1  - Mewes, Caspar
A1  - Schmack, Bastian
A1  - Popov, Aron Frederik
A1  - Ghadimi, Michael
A1  - Beissbarth, Tim
A1  - Hinz, José
A1  - Bergmann, Ingo
A1  - Mansur, Ashham
JF  - BMC Research Notes
N2  - Objective: The mortality associated with sepsis remains unacceptably high, despite modern high-quality intensive care. Based on the results from previous studies, anaemia and its management in patients with sepsis appear to impact outcomes; however, the transfusion policy is still being debated, and the ideal approach may be extremely specific to the individual. This study aimed to investigate the long-term impact of anaemia requiring red blood cell (RBC) transfusion on mortality and disease severity in patients with sepsis. We studied a general surgical intensive care unit (ICU) population, excluding cardiac surgery patients. 435 patients were enrolled in this observational study between 2012 and 2016.

Results: Patients who received RBC transfusion between 28 days before and 28 days after the development of sepsis (n?=?302) exhibited a significantly higher 90-day mortality rate (34.1% vs 19.6%; P?=?0.004, Kaplan?Meier analysis). This association remained significant after adjusting for confounders in the multivariate Cox regression analysis (hazard ratio 1.68; 95% confidence interval 1.03?2.73; P?=?0.035). Patients who received transfusions also showed significantly higher morbidity scores, such as SOFA scores, and ICU lengths of stay compared to patients without transfusions (n?=?133). Our results indicate that anaemia and RBC transfusion are associated with unfavourable outcomes in patients with sepsis.
AV  - public
UR  - https://archiv.ub.uni-heidelberg.de/volltextserver/25746/
CY  - London
PB  - BioMed Central
TI  - Anaemia requiring red blood cell transfusion is associated with unfavourable 90-day survival in surgical patients with sepsis
ER  -