<> "The repository administrator has not yet configured an RDF license."^^ . <> . . "ADP dependent glucokinase as a novel onco-target for haematological malignancies."^^ . "In this study we aimed at studying the tumor aggressiveness and differentiation potential of Ramos Burkitt’s lymphoma cells upon mitogenic stimulation in light of a novel regulator of immune cell metabolism and activation, ADPGK. We have identified the role of ADPGK in regulation of aerobic glycolysis in Burkitt’s Lymphoma cells and shown that its knock-out leads to reduced tumor aggressiveness, as measured in-vitro via co-culture, migration experiments and metabolic profile, and in-vivo Zebrafish. We found significantly reduced MYC transcription in ADPGK knock-out Burkitt’s lymphoma cells and importantly, several folds reduction in accumulated random mutations in translocated MYC in these cells. We additionally observed a stalled pathway to differentiation of ADPGK knock out B-cells into plasma cells upon stimulation by mitogenic signals. Overall, the study provided the first insights into the role of a novel ER resident protein acting as a regulator of two complementary phenomenon, cell-differentiation and cancer aggressiveness, and thereby opens up new possibilities of therapeutic interventions for hematopoietic malignancies."^^ . "2018" . . . . . . . "Amol"^^ . "Tandon"^^ . "Amol Tandon"^^ . . . . . . "ADP dependent glucokinase as a novel onco-target for haematological malignancies. (PDF)"^^ . . . "Amol_PhD Thesis.pdf"^^ . . . "ADP dependent glucokinase as a novel onco-target for haematological malignancies. (Other)"^^ . . . . . . "lightbox.jpg"^^ . . . "ADP dependent glucokinase as a novel onco-target for haematological malignancies. (Other)"^^ . . . . . . "preview.jpg"^^ . . . "ADP dependent glucokinase as a novel onco-target for haematological malignancies. (Other)"^^ . . . . . . "medium.jpg"^^ . . . "ADP dependent glucokinase as a novel onco-target for haematological malignancies. (Other)"^^ . . . . . . "small.jpg"^^ . . . "ADP dependent glucokinase as a novel onco-target for haematological malignancies. (Other)"^^ . . . . . . "indexcodes.txt"^^ . . "HTML Summary of #25779 \n\nADP dependent glucokinase as a novel onco-target for haematological malignancies.\n\n" . "text/html" . . . "500 Naturwissenschaften und Mathematik"@de . "500 Natural sciences and mathematics"@en . . . "570 Biowissenschaften, Biologie"@de . "570 Life sciences"@en . .