<> "The repository administrator has not yet configured an RDF license."^^ . <> . . . "Right ventricular size and function under riociguat in pulmonary arterial hypertension and chronic thromboembolic pulmonary hypertension (the RIVER study)"^^ . "Background: Riociguat is a soluble guanylate cyclase stimulator approved for pulmonary arterial hypertension (PAH) and chronic thromboembolic pulmonary hypertension (CTPEH). The objective of this study was to evaluate right heart size and function assessed by echocardiography during long term treatment with riociguat.\r\n\r\nMethods: Patients who started riociguat treatment (1.0–2.5 mg tid) within the trials phase II, PATENT, PATENTplus, EAS, CHEST and continued treatment for 3–12 months were included in this study. Echocardiography was analysed off-line at baseline, after 3, 6 and 12 months by investigators who were blinded to clinical data. Last and baseline observation carried forward method (LOCF, BOCF) were performed as sensitivity analysis.\r\n\r\nResults: Seventy-one patients (45% PAH, 55% CTEPH; 53.5% female; 60 ± 13 years, mean pulmonary arterial pressure 46 ± 10 mmHg, mean PVR 700 ± 282dynes·sec·cm-5) were included. After 6 months, RA and RV area, RV thickness tricuspid regurgitation velocity showed a significant reduction. After 12 months, patients receiving riociguat therapy showed a significant reduction in right atrial (− 2.6 ± 4.4 cm2, 95% CI -3.84, − 1.33; p < 0.001, n = 49) and right ventricular (RV) area (− 3.5 ± 5.2 cm2, 95% CI -5.1, − 1.9; p < 0.001; n = 44), RV thickness (− 0.76 ± 2.2 mm, 95% CI -1.55, 0.03; n = 32), and a significant increase in TAPSE (2.95 ± 4.78 mm, 95% CI 1.52, 4.39; n = 45) and RV fractional area change (8.12 ± 8.87 mm, 95% CI 4.61, 11.62; n = 27). Both LOCF and BOCF showed similar results but lower effect sizes. \r\n\r\nConclusion: Patients under long-term treatment with riociguat show significantly reduced right heart size and improved RV function in PAH and CTEPH. Further controlled prospective studies are needed to confirm these results."^^ . "2018" . . "19" . "258" . . "BioMed Central"^^ . . . "Respiratory Research"^^ . . . "1465993X" . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . "Alberto M."^^ . "Marra"^^ . "Alberto M. Marra"^^ . . "Christina A."^^ . "Eichstaedt"^^ . "Christina A. Eichstaedt"^^ . . "Marius M."^^ . "Hoeper"^^ . "Marius M. Hoeper"^^ . . "Antonio"^^ . "Cittadini"^^ . "Antonio Cittadini"^^ . . "Satenik"^^ . "Harutyunova"^^ . "Satenik Harutyunova"^^ . . "Hossein Ardeschir"^^ . "Ghofrani"^^ . "Hossein Ardeschir Ghofrani"^^ . . "Eduardo"^^ . "Bossone"^^ . "Eduardo Bossone"^^ . . "Christine"^^ . "Fischer"^^ . "Christine Fischer"^^ . . "Hans"^^ . "Klose"^^ . "Hans Klose"^^ . . "Tobias J."^^ . "Lange"^^ . "Tobias J. Lange"^^ . . "Ekkehard"^^ . "Grünig"^^ . "Ekkehard Grünig"^^ . . "Karen M."^^ . "Olsson"^^ . "Karen M. Olsson"^^ . . "Benjamin"^^ . "Egenlauf"^^ . "Benjamin Egenlauf"^^ . . "Michael"^^ . "Halank"^^ . "Michael Halank"^^ . . "Henning"^^ . "Gall"^^ . "Henning Gall"^^ . . "Nicola"^^ . "Benjamin"^^ . "Nicola Benjamin"^^ . . . . . . "Right ventricular size and function under riociguat in pulmonary arterial hypertension and chronic thromboembolic pulmonary hypertension (the RIVER study) (PDF)"^^ . . . "12931_2018_Article_957.pdf"^^ . . . "Right ventricular size and function under riociguat in pulmonary arterial hypertension and chronic thromboembolic pulmonary hypertension (the RIVER study) (Other)"^^ . . . . . . "lightbox.jpg"^^ . . . "Right ventricular size and function under riociguat in pulmonary arterial hypertension and chronic thromboembolic pulmonary hypertension (the RIVER study) (Other)"^^ . . . . . . "preview.jpg"^^ . . . "Right ventricular size and function under riociguat in pulmonary arterial hypertension and chronic thromboembolic pulmonary hypertension (the RIVER study) (Other)"^^ . . . . . . "medium.jpg"^^ . . . "Right ventricular size and function under riociguat in pulmonary arterial hypertension and chronic thromboembolic pulmonary hypertension (the RIVER study) (Other)"^^ . . . . . . "small.jpg"^^ . . . "Right ventricular size and function under riociguat in pulmonary arterial hypertension and chronic thromboembolic pulmonary hypertension (the RIVER study) (Other)"^^ . . . . . . "indexcodes.txt"^^ . . "HTML Summary of #25795 \n\nRight ventricular size and function under riociguat in pulmonary arterial hypertension and chronic thromboembolic pulmonary hypertension (the RIVER study)\n\n" . "text/html" . . . "610 Medizin"@de . "610 Medical sciences Medicine"@en . .