eprintid: 25801
rev_number: 13
eprint_status: archive
userid: 1589
dir: disk0/00/02/58/01
datestamp: 2019-02-08 12:03:43
lastmod: 2021-08-06 09:29:50
status_changed: 2019-02-08 12:03:43
type: article
metadata_visibility: show
creators_name: Sommerer, Claudia
creators_name: Estelmann, Sarah
creators_name: Metzendorf, Nicole G.
creators_name: Leuschner, Maren
creators_name: Zeier, Martin
title: Gender disparity in health-related quality of life and fatigue after living renal donation
subjects: 610
divisions: 910100
divisions: 910700
keywords: Living renal donation, Gender, Quality of life, Fatigue, Depression
abstract: Background: The clinical outcome and health-related quality of life (HRQoL) of living kidney donors is mostly not detrimental, but some donors experience impairment after donation. Gender-specific effects of living kidney donors was evaluated.

Methods: Clinical outcome was assessed in living kidney donors and HRQoL was obtained by self-reporting validated test systems as the Multidimensional Fatigue Inventory (MFI-20), the Short Form 36 (SF-36), and the Patient Health Questionnaire (PHQ-9).

Results: Two hundred and eleven (211) living renal donors were evaluated (female 62.2%). Response rate was 80.8%. In both genders, a decrease of renal function of 26% was observed after donation. De novo antihypertensives were introduced in 28.3% of women and 36.5% of men. HRQoL was comparable in female and male donors, except for mental HRQoL, which was lower in 51- to 60-year-old female donors, compared to age-matched male donors and to the female general population. Female donors aged 40–59 years demonstrated more fatigue than the age-matched general population. A low mental HRQoL (MCS; SF-36) was associated with higher values for fatigue (General Fatigue Score; MFI-20) in both genders. Multiple regression analysis detected the General Fatigue score of the MFI-20 questionnaire and depression identified by the PHQ-9 score as independent variables predicting MCS of the SF-36 in both genders. Lower age at time of donation contributed to a lower MCS in female donors.

Conclusions: Overall, HRQoL in living kidney donors exceeds that of the general population. Inferior mental health status and fatigue seem to be a problem, especially in middle-aged female donors, but not in all female donors. Psychological evaluation pre donation and psychological support post donation are required.
date: 2018
publisher: BioMed Central
id_scheme: DOI
id_number: https://doi.org/10.1186/s12882-018-1187-8
ppn_swb: 1765883016
own_urn: urn:nbn:de:bsz:16-heidok-258010
language: eng
bibsort: SOMMERERCLGENDERDISP2018
full_text_status: public
publication: BMC Nephrology
volume: 19
number: 377
place_of_pub: London
pagerange: 1-10
issn: 1471-2369
citation:   Sommerer, Claudia ; Estelmann, Sarah ; Metzendorf, Nicole G. ; Leuschner, Maren ; Zeier, Martin  (2018) Gender disparity in health-related quality of life and fatigue after living renal donation.  BMC Nephrology, 19 (377).  pp. 1-10.  ISSN 1471-2369     
document_url: https://archiv.ub.uni-heidelberg.de/volltextserver/25801/1/12882_2018_Article_1187.pdf