title: An 8-week diet high in cereal fiber and coffee but free of red meat does not improve beta-cell function in patients with type 2 diabetes mellitus: a randomized controlled trial
creator: Karusheva, Yanislava
creator: Kunstein, Lejla
creator: Bierwagen, Alessandra
creator: Nowotny, Bettina
creator: Kabisch, Stefan
creator: Groener, Jan B.
creator: Fleitmann, Ann Kristin
creator: Herder, Christian
creator: Pacini, Giovanni
creator: Strassburger, Klaus
creator: Häring, Hans-Ulrich
creator: Nawroth, Peter P.
creator: Pfeiffer, Andreas F. H.
creator: Burkart, Volker
creator: Müssig, Karsten
creator: Roden, Michael
creator: Szendroedi, Julia
subject: ddc-610
subject: 610 Medical sciences Medicine
description: Background: Higher dietary intake of fibers and coffee, but lower red meat intake is associated with reduced risk for type 2 diabetes in epidemiological studies. We hypothesized that a calorie-restricted diet, which is high in fiber and coffee, but free of red meat, improves beta-cell function in patients with T2D.       Methods: In a randomized parallel-group pilot trial, obese type 2 diabetes patients were randomly allocated to consume either a diet high in cereal fiber and coffee, but free of red meat (n = 17) (L-RISK) or a diet low in fiber, free of coffee but high in red meat (n = 20) (H-RISK) for 8 weeks. Insulin secretion was assessed from glucagon stimulation tests (GST) and mixed-meal tolerance tests (MMTT) before and after dietary intervention.     Results: Both diets resulted in comparable reduction of fasting concentrations of insulin (H-RISK -28% vs. L-RISK -32%, both p < 0.01), C-peptide (H-RISK -26% vs. L-RISK -30%, both p < 0.01) and blood glucose (H-RISK -6.8%, p < 0.05 vs. L-RISK -10%, p < 0.01). Gastric inhibitory peptide (GIP) secretion increased by 24% after 8 weeks in the L-RISK only (p < 0.01). However, GST and MMTT showed no differences in insulin secretion after intervention.    Conclusions: Calorie restriction independent of the intake of fiber, coffee or meat failed to improve beta-cell function, but improved GIP secretion in obese patients with type 2 diabetes.      Trial registration: Registration at Clinicaltrials.gov, Identifier number: NCT01409330  , Registered 4 August 2011 – Retrospectively registered.
publisher: BioMed Central
date: 2018
type: Article
type: info:eu-repo/semantics/article
type: NonPeerReviewed
format: application/pdf
identifier: https://archiv.ub.uni-heidelberg.de/volltextserverhttps://archiv.ub.uni-heidelberg.de/volltextserver/25805/1/12986_2018_Article_324.pdf
identifier: DOI:
identifier: urn:nbn:de:bsz:16-heidok-258052
identifier:   Karusheva, Yanislava ; Kunstein, Lejla ; Bierwagen, Alessandra ; Nowotny, Bettina ; Kabisch, Stefan ; Groener, Jan B. ; Fleitmann, Ann Kristin ; Herder, Christian ; Pacini, Giovanni ; Strassburger, Klaus ; Häring, Hans-Ulrich ; Nawroth, Peter P. ; Pfeiffer, Andreas F. H. ; Burkart, Volker ; Müssig, Karsten ; Roden, Michael ; Szendroedi, Julia  (2018) An 8-week diet high in cereal fiber and coffee but free of red meat does not improve beta-cell function in patients with type 2 diabetes mellitus: a randomized controlled trial.  Nutrition & Metabolism, 15 (90).  pp. 1-8.  ISSN 1743-7075     
relation: https://archiv.ub.uni-heidelberg.de/volltextserver/25805/
rights: info:eu-repo/semantics/openAccess
rights: Please see front page of the work (Sorry, Dublin Core plugin does not recognise license id)
language: eng