<> "The repository administrator has not yet configured an RDF license."^^ . <> . . . "An 8-week diet high in cereal fiber and coffee but free of red meat does not improve beta-cell function in patients with type 2 diabetes mellitus: a randomized controlled trial"^^ . "Background: Higher dietary intake of fibers and coffee, but lower red meat intake is associated with reduced risk for type 2 diabetes in epidemiological studies. We hypothesized that a calorie-restricted diet, which is high in fiber and coffee, but free of red meat, improves beta-cell function in patients with T2D. \r\n\r\nMethods: In a randomized parallel-group pilot trial, obese type 2 diabetes patients were randomly allocated to consume either a diet high in cereal fiber and coffee, but free of red meat (n = 17) (L-RISK) or a diet low in fiber, free of coffee but high in red meat (n = 20) (H-RISK) for 8 weeks. Insulin secretion was assessed from glucagon stimulation tests (GST) and mixed-meal tolerance tests (MMTT) before and after dietary intervention. \r\n\r\nResults: Both diets resulted in comparable reduction of fasting concentrations of insulin (H-RISK -28% vs. L-RISK -32%, both p < 0.01), C-peptide (H-RISK -26% vs. L-RISK -30%, both p < 0.01) and blood glucose (H-RISK -6.8%, p < 0.05 vs. L-RISK -10%, p < 0.01). Gastric inhibitory peptide (GIP) secretion increased by 24% after 8 weeks in the L-RISK only (p < 0.01). However, GST and MMTT showed no differences in insulin secretion after intervention.\r\n\r\nConclusions: Calorie restriction independent of the intake of fiber, coffee or meat failed to improve beta-cell function, but improved GIP secretion in obese patients with type 2 diabetes. \r\n\r\nTrial registration: Registration at Clinicaltrials.gov, Identifier number: NCT01409330 , Registered 4 August 2011 – Retrospectively registered."^^ . "2018" . . "15" . "90" . . "BioMed Central"^^ . . . "Nutrition & Metabolism"^^ . . . "17437075" . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . "Julia"^^ . "Szendroedi"^^ . "Julia Szendroedi"^^ . . "Jan B."^^ . "Groener"^^ . "Jan B. Groener"^^ . . "Hans-Ulrich"^^ . "Häring"^^ . "Hans-Ulrich Häring"^^ . . "Stefan"^^ . "Kabisch"^^ . "Stefan Kabisch"^^ . . "Ann Kristin"^^ . "Fleitmann"^^ . "Ann Kristin Fleitmann"^^ . . "Yanislava"^^ . "Karusheva"^^ . "Yanislava Karusheva"^^ . . "Lejla"^^ . "Kunstein"^^ . "Lejla Kunstein"^^ . . "Michael"^^ . "Roden"^^ . "Michael Roden"^^ . . "Volker"^^ . "Burkart"^^ . "Volker Burkart"^^ . . "Peter P."^^ . "Nawroth"^^ . "Peter P. Nawroth"^^ . . "Christian"^^ . "Herder"^^ . "Christian Herder"^^ . . "Klaus"^^ . "Strassburger"^^ . "Klaus Strassburger"^^ . . "Alessandra"^^ . "Bierwagen"^^ . "Alessandra Bierwagen"^^ . . "Andreas F. H."^^ . "Pfeiffer"^^ . "Andreas F. H. Pfeiffer"^^ . . "Bettina"^^ . "Nowotny"^^ . "Bettina Nowotny"^^ . . "Karsten"^^ . "Müssig"^^ . "Karsten Müssig"^^ . . "Giovanni"^^ . "Pacini"^^ . "Giovanni Pacini"^^ . . . . . . "An 8-week diet high in cereal fiber and coffee but free of red meat does not improve beta-cell function in patients with type 2 diabetes mellitus: a randomized controlled trial (PDF)"^^ . . . "12986_2018_Article_324.pdf"^^ . . . "An 8-week diet high in cereal fiber and coffee but free of red meat does not improve beta-cell function in patients with type 2 diabetes mellitus: a randomized controlled trial (Other)"^^ . . . . . . "indexcodes.txt"^^ . . . "An 8-week diet high in cereal fiber and coffee but free of red meat does not improve beta-cell function in patients with type 2 diabetes mellitus: a randomized controlled trial (Other)"^^ . . . . . . "lightbox.jpg"^^ . . . "An 8-week diet high in cereal fiber and coffee but free of red meat does not improve beta-cell function in patients with type 2 diabetes mellitus: a randomized controlled trial (Other)"^^ . . . . . . "preview.jpg"^^ . . . "An 8-week diet high in cereal fiber and coffee but free of red meat does not improve beta-cell function in patients with type 2 diabetes mellitus: a randomized controlled trial (Other)"^^ . . . . . . "medium.jpg"^^ . . . "An 8-week diet high in cereal fiber and coffee but free of red meat does not improve beta-cell function in patients with type 2 diabetes mellitus: a randomized controlled trial (Other)"^^ . . . . . . "small.jpg"^^ . . "HTML Summary of #25805 \n\nAn 8-week diet high in cereal fiber and coffee but free of red meat does not improve beta-cell function in patients with type 2 diabetes mellitus: a randomized controlled trial\n\n" . "text/html" . . . "610 Medizin"@de . "610 Medical sciences Medicine"@en . .