TY  - JOUR
PB  - BioMed Central
VL  - 15
ID  - heidok25805
AV  - public
IS  - 90
CY  - London
EP  - 8
UR  - https://archiv.ub.uni-heidelberg.de/volltextserver/25805/
N2  - Background: Higher dietary intake of fibers and coffee, but lower red meat intake is associated with reduced risk for type 2 diabetes in epidemiological studies. We hypothesized that a calorie-restricted diet, which is high in fiber and coffee, but free of red meat, improves beta-cell function in patients with T2D.   

Methods: In a randomized parallel-group pilot trial, obese type 2 diabetes patients were randomly allocated to consume either a diet high in cereal fiber and coffee, but free of red meat (n =?17) (L-RISK) or a diet low in fiber, free of coffee but high in red meat (n =?20) (H-RISK) for 8?weeks. Insulin secretion was assessed from glucagon stimulation tests (GST) and mixed-meal tolerance tests (MMTT) before and after dietary intervention. 

Results: Both diets resulted in comparable reduction of fasting concentrations of insulin (H-RISK -28% vs. L-RISK -32%, both p <?0.01), C-peptide (H-RISK -26% vs. L-RISK -30%, both p <?0.01) and blood glucose (H-RISK -6.8%, p <?0.05 vs. L-RISK -10%, p <?0.01). Gastric inhibitory peptide (GIP) secretion increased by 24% after 8?weeks in the L-RISK only (p <?0.01). However, GST and MMTT showed no differences in insulin secretion after intervention.

Conclusions: Calorie restriction independent of the intake of fiber, coffee or meat failed to improve beta-cell function, but improved GIP secretion in obese patients with type 2 diabetes.  

Trial registration: Registration at Clinicaltrials.gov, Identifier number: NCT01409330  , Registered 4 August 2011 ? Retrospectively registered.
JF  - Nutrition & Metabolism
A1  - Karusheva, Yanislava
A1  - Kunstein, Lejla
A1  - Bierwagen, Alessandra
A1  - Nowotny, Bettina
A1  - Kabisch, Stefan
A1  - Groener, Jan B.
A1  - Fleitmann, Ann Kristin
A1  - Herder, Christian
A1  - Pacini, Giovanni
A1  - Strassburger, Klaus
A1  - Häring, Hans-Ulrich
A1  - Nawroth, Peter P.
A1  - Pfeiffer, Andreas F. H.
A1  - Burkart, Volker
A1  - Müssig, Karsten
A1  - Roden, Michael
A1  - Szendroedi, Julia
SP  - 1
Y1  - 2018///
TI  - An 8-week diet high in cereal fiber and coffee but free of red meat does not improve beta-cell function in patients with type 2 diabetes mellitus: a randomized controlled trial
SN  - 1743-7075
ER  -