eprintid: 25805 rev_number: 11 eprint_status: archive userid: 1589 dir: disk0/00/02/58/05 datestamp: 2019-01-10 10:15:15 lastmod: 2024-03-30 19:07:45 status_changed: 2019-01-10 10:15:15 type: article metadata_visibility: show creators_name: Karusheva, Yanislava creators_name: Kunstein, Lejla creators_name: Bierwagen, Alessandra creators_name: Nowotny, Bettina creators_name: Kabisch, Stefan creators_name: Groener, Jan B. creators_name: Fleitmann, Ann Kristin creators_name: Herder, Christian creators_name: Pacini, Giovanni creators_name: Strassburger, Klaus creators_name: Häring, Hans-Ulrich creators_name: Nawroth, Peter P. creators_name: Pfeiffer, Andreas F. H. creators_name: Burkart, Volker creators_name: Müssig, Karsten creators_name: Roden, Michael creators_name: Szendroedi, Julia title: An 8-week diet high in cereal fiber and coffee but free of red meat does not improve beta-cell function in patients with type 2 diabetes mellitus: a randomized controlled trial subjects: ddc-610 divisions: i-910100 abstract: Background: Higher dietary intake of fibers and coffee, but lower red meat intake is associated with reduced risk for type 2 diabetes in epidemiological studies. We hypothesized that a calorie-restricted diet, which is high in fiber and coffee, but free of red meat, improves beta-cell function in patients with T2D. Methods: In a randomized parallel-group pilot trial, obese type 2 diabetes patients were randomly allocated to consume either a diet high in cereal fiber and coffee, but free of red meat (n = 17) (L-RISK) or a diet low in fiber, free of coffee but high in red meat (n = 20) (H-RISK) for 8 weeks. Insulin secretion was assessed from glucagon stimulation tests (GST) and mixed-meal tolerance tests (MMTT) before and after dietary intervention. Results: Both diets resulted in comparable reduction of fasting concentrations of insulin (H-RISK -28% vs. L-RISK -32%, both p < 0.01), C-peptide (H-RISK -26% vs. L-RISK -30%, both p < 0.01) and blood glucose (H-RISK -6.8%, p < 0.05 vs. L-RISK -10%, p < 0.01). Gastric inhibitory peptide (GIP) secretion increased by 24% after 8 weeks in the L-RISK only (p < 0.01). However, GST and MMTT showed no differences in insulin secretion after intervention. Conclusions: Calorie restriction independent of the intake of fiber, coffee or meat failed to improve beta-cell function, but improved GIP secretion in obese patients with type 2 diabetes. Trial registration: Registration at Clinicaltrials.gov, Identifier number: NCT01409330 , Registered 4 August 2011 – Retrospectively registered. date: 2018 publisher: BioMed Central id_scheme: DOI ppn_swb: 1655161903 own_urn: urn:nbn:de:bsz:16-heidok-258052 language: eng bibsort: KARUSHEVAYAN8WEEKDIE2018 full_text_status: public publication: Nutrition & Metabolism volume: 15 number: 90 place_of_pub: London pagerange: 1-8 issn: 1743-7075 citation: Karusheva, Yanislava ; Kunstein, Lejla ; Bierwagen, Alessandra ; Nowotny, Bettina ; Kabisch, Stefan ; Groener, Jan B. ; Fleitmann, Ann Kristin ; Herder, Christian ; Pacini, Giovanni ; Strassburger, Klaus ; Häring, Hans-Ulrich ; Nawroth, Peter P. ; Pfeiffer, Andreas F. H. ; Burkart, Volker ; Müssig, Karsten ; Roden, Michael ; Szendroedi, Julia (2018) An 8-week diet high in cereal fiber and coffee but free of red meat does not improve beta-cell function in patients with type 2 diabetes mellitus: a randomized controlled trial. Nutrition & Metabolism, 15 (90). pp. 1-8. ISSN 1743-7075 document_url: https://archiv.ub.uni-heidelberg.de/volltextserver/25805/1/12986_2018_Article_324.pdf