TY  - JOUR
VL  - 19
EP  - 8
Y1  - 2019///
JF  - BMC Infectious Diseases
CY  - London ; Berlin ; Heidelberg
KW  - German National Cohort
KW  -  Incidence
KW  -  Self-reports
KW  -  Validity
KW  -  Herpes zoster
KW  -  Postherpetic neuralgia
PB  - BioMed Central ; Springer
SP  - 1
AV  - public
N2  - Background: Until now, herpes zoster (HZ)-related disease burden in Germany has been estimated based on health insurance data and clinical findings. However, the validity of self-reported HZ is unclear. This study investigated the validity of self-reported herpes zoster (HZ) and its complication postherpetic neuralgia (PHN) using data from the pretest studies of the German National Cohort (GNC) in comparison with estimates based on health insurance data.

Methods: Data of 4751 participants aged between 20 and 69?years from two pretest studies of the GNC carried out in 2011 and 2012 were used. Based on self-reports of physician-diagnosed HZ and PHN, age- and sex-specific HZ incidence rates and PHN proportions were estimated. For comparison, estimates based on statutory health insurance data from the German population were considered.

Results: Eleven percent (95%-CI, 10.4 to 12.3, n?=?539) of the participants reported at least one HZ episode in their lifetime. Our estimated age-specific HZ incidence rates were lower than previous estimates based on statutory health insurance data. The PHN proportion in participants older than 50?years was 5.9% (1.9 to 13.9%), which was in line with estimates based on health insurance data.

Conclusion: As age- and sex-specific patterns were comparable with that in health insurance data, self-reported diagnosis of HZ seems to be a valid instrument for overall disease trends. Possible reasons for observed differences in incidence rates are recall bias in self-reported data or overestimation in health insurance data.
TI  - Herpes zoster incidence in Germany - an indirect validation study for self-reported disease data from pretest studies of the population-based German National Cohort
UR  - https://archiv.ub.uni-heidelberg.de/volltextserver/26011/
ID  - heidok26011
SN  - 1471-2334
IS  - 99
A1  - Caputo, Mahrrouz
A1  - Horn, Johannes
A1  - Karch, André
A1  - Akmatov, Manas K.
A1  - Becher, Heiko
A1  - Braun, Bettina
A1  - Brenner, Hermann
A1  - Castell, Stefanie
A1  - Fischer, Beate
A1  - Giani, Guido
A1  - Günther, Kathrin
A1  - Hoffmann, Barbara
A1  - Jöckel, Karl-Heinz
A1  - Keil, Thomas
A1  - Klüppelholz, Birgit
A1  - Krist, Lilian
A1  - Leitzmann, Michael F.
A1  - Lieb, Wolfgang
A1  - Linseisen, Jakob
A1  - Meisinger, Christa
A1  - Moebus, Susanne
A1  - Obi, Nadia
A1  - Pischon, Tobias
A1  - Schipf, Sabine
A1  - Schmidt, Börge
A1  - Sievers, Claudia
A1  - Steinbrecher, Astrid
A1  - Völzke, Henry
A1  - Mikolajczyk, Rafael
ER  -