eprintid: 26011
rev_number: 16
eprint_status: archive
userid: 1589
dir: disk0/00/02/60/11
datestamp: 2019-03-12 16:54:50
lastmod: 2024-05-25 06:04:25
status_changed: 2019-03-12 16:54:50
type: article
metadata_visibility: show
creators_name: Caputo, Mahrrouz
creators_name: Horn, Johannes
creators_name: Karch, André
creators_name: Akmatov, Manas K.
creators_name: Becher, Heiko
creators_name: Braun, Bettina
creators_name: Brenner, Hermann
creators_name: Castell, Stefanie
creators_name: Fischer, Beate
creators_name: Giani, Guido
creators_name: Günther, Kathrin
creators_name: Hoffmann, Barbara
creators_name: Jöckel, Karl-Heinz
creators_name: Keil, Thomas
creators_name: Klüppelholz, Birgit
creators_name: Krist, Lilian
creators_name: Leitzmann, Michael F.
creators_name: Lieb, Wolfgang
creators_name: Linseisen, Jakob
creators_name: Meisinger, Christa
creators_name: Moebus, Susanne
creators_name: Obi, Nadia
creators_name: Pischon, Tobias
creators_name: Schipf, Sabine
creators_name: Schmidt, Börge
creators_name: Sievers, Claudia
creators_name: Steinbrecher, Astrid
creators_name: Völzke, Henry
creators_name: Mikolajczyk, Rafael
title: Herpes zoster incidence in Germany - an indirect validation study for self-reported disease data from pretest studies of the population-based German National Cohort
subjects: ddc-610
divisions: i-850300
divisions: i-851600
divisions: i-912800
keywords: German National Cohort, Incidence, Self-reports, Validity, Herpes zoster, Postherpetic neuralgia
abstract: Background: Until now, herpes zoster (HZ)-related disease burden in Germany has been estimated based on health insurance data and clinical findings. However, the validity of self-reported HZ is unclear. This study investigated the validity of self-reported herpes zoster (HZ) and its complication postherpetic neuralgia (PHN) using data from the pretest studies of the German National Cohort (GNC) in comparison with estimates based on health insurance data.

Methods: Data of 4751 participants aged between 20 and 69 years from two pretest studies of the GNC carried out in 2011 and 2012 were used. Based on self-reports of physician-diagnosed HZ and PHN, age- and sex-specific HZ incidence rates and PHN proportions were estimated. For comparison, estimates based on statutory health insurance data from the German population were considered.

Results: Eleven percent (95%-CI, 10.4 to 12.3, n = 539) of the participants reported at least one HZ episode in their lifetime. Our estimated age-specific HZ incidence rates were lower than previous estimates based on statutory health insurance data. The PHN proportion in participants older than 50 years was 5.9% (1.9 to 13.9%), which was in line with estimates based on health insurance data.

Conclusion: As age- and sex-specific patterns were comparable with that in health insurance data, self-reported diagnosis of HZ seems to be a valid instrument for overall disease trends. Possible reasons for observed differences in incidence rates are recall bias in self-reported data or overestimation in health insurance data.
date: 2019
publisher: BioMed Central ; Springer
id_scheme: DOI
ppn_swb: 1665056428
own_urn: urn:nbn:de:bsz:16-heidok-260117
language: eng
bibsort: CAPUTOMAHRHERPESZOST2019
full_text_status: public
publication: BMC Infectious Diseases
volume: 19
number: 99
place_of_pub: London ; Berlin ; Heidelberg
pagerange: 1-8
issn: 1471-2334
citation:   Caputo, Mahrrouz ; Horn, Johannes ; Karch, André ; Akmatov, Manas K. ; Becher, Heiko ; Braun, Bettina ; Brenner, Hermann ; Castell, Stefanie ; Fischer, Beate ; Giani, Guido ; Günther, Kathrin ; Hoffmann, Barbara ; Jöckel, Karl-Heinz ; Keil, Thomas ; Klüppelholz, Birgit ; Krist, Lilian ; Leitzmann, Michael F. ; Lieb, Wolfgang ; Linseisen, Jakob ; Meisinger, Christa ; Moebus, Susanne ; Obi, Nadia ; Pischon, Tobias ; Schipf, Sabine ; Schmidt, Börge ; Sievers, Claudia ; Steinbrecher, Astrid ; Völzke, Henry ; Mikolajczyk, Rafael  (2019) Herpes zoster incidence in Germany - an indirect validation study for self-reported disease data from pretest studies of the population-based German National Cohort.  BMC Infectious Diseases, 19 (99).  pp. 1-8.  ISSN 1471-2334     
document_url: https://archiv.ub.uni-heidelberg.de/volltextserver/26011/1/12879_2019_Article_3691.pdf